Abstract

Pyrazolo-pyrimidino-pyridazine derivatives are potent compounds with pharmacological activities like anti-inflammatory, analgesic and anti-microbial. Pharmacological screenings proved that the compounds 1 to 6 had high activities comparable with reference drugs. Anti-inflammatory evaluation of the tested compounds comparable with Indomethacin showed that edema inhibition increased with time. All the tested compounds had no gastric ulcerogenic effect on mice. Also, analgesic activity of the tested compounds comparable with valdecoxib showed that these compounds had activities. Analgesic activities of the tested compounds increased with time. The tested compounds were able to inhibit the growth of the Gram-positive, Gram-negative bacteria and fungi.

Key words: New hetero cyclic compounds, pharmacological screening, anti-inflammatory, analgesic, anti-microbial.