African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Production of gastro-resistant coated tablets prepared from the hydroethanolic standardized roots extract of Harpagophytum procumbens DC.

Andrey Pereira Lopes
  • Andrey Pereira Lopes
  • Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
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Bianca Souza Bagatela
  • Bianca Souza Bagatela
  • Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
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Ivan Pereira Lopes
  • Ivan Pereira Lopes
  • Center for Research in Haematology and Oncology, ABC Medical School, Santo André, São Paulo, Brazil.
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Luiz Elidio Gregório
  • Luiz Elidio Gregório
  • Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
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Edson Luis Maistro
  • Edson Luis Maistro
  • Faculty of Sciences, State University of São Paulo, Marilia, São Paulo, Brazil.
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Fernando Luiz Affonso Fonseca
  • Fernando Luiz Affonso Fonseca
  • Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
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Fábio Ferreira Perazzo
  • Fábio Ferreira Perazzo
  • Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil.
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  •  Received: 27 August 2017
  •  Accepted: 26 September 2017
  •  Published: 15 October 2017

Abstract

This project aimed at developing a gastro-resistant coated tablet using traditional herbal medicine dry extract from the secondary roots of the plant species Harpagophytum procumbens DC. (Pedaliaceae), standardized in harpagoside 20%, popularly known as "devil's claw". The tablets were produced by direct compression and coated with the gastro-resistant dispersion. Accelerated and long-term stability studies were performed to define the period of use and validity. The tablets present a high dose of chemical markers differently from the usual pharmaceutical forms, diminishing the daily doses to 1 or 2 tablets. The hardness, friability, weigh and thickness were in agreement with the Brazilian Pharmacopeia 5th Edition. The analytical method used was validated to confirm the assays. The gastro-resistant coated tablets, obtained from the dried extract of H. procumbens DC., standardized in harpagoside 20%, was stable after the accelerated study and the analytical methodology was validated.

Key words: Pedaliaceae, Harpagophytum procumbens DC., devil's claw, traditional herbal medicine, gastro-resistant coated tablets.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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