Abstract

The present investigation designed to evaluate the phytochemical and pharmacological activity of ethanolic extract of Solanum nigrum in experimental animal models. The ethanolic extract of S. nigrum was used in three different doses (100, 200 and 300 mg/kg bw) to evaluating anti-inflammatory and anti-convulsant activity by employing carrageenan paw edema and Supramaximal electric shock (MES) methods. Ethanolic extract of S. nigrum produced significant anti-inflammatory (P < 0.01) and anti-convulsant (P < 0.05) effect in dose dependent manner. The flavonoids present in the berries might be a responsible active constituent for this activity.

Key words: Solanum nigrum, anti-inflammatory activity, anti-convulsant, flavonoids