Abstract

Nanoparticles are of current interest because of their emerging understanding effects on human health. Many developed nanoparticles were created based upon the current application. The application of nanoparticles in drug delivery of pharmaceuticals offers many advantages on the treatment strategies and therapy outcomes. Poly-beta-hydroxyl-butyrate (PHB) nanoparticles are very versatile and its design could be tailored to the needs of individual drug. Biodegradable polymeric PHB are able to provide controlled release of the encapsulated drug and it could be prolonged or enhanced. The emergence of PHB group of polymers as a potential cheap biomaterial may also become an interesting alternative in the production and controlled release manner. The Global Tuberculosis Report published by WHO revealed an increasing incidence of drug resistance and patients need to be treated for the period of 18 to 24 months using second line, anti- tuberculosis (TB) drug. Rifampicin, an anti tuberculosis drug, was chosen to incorporate in both types of nanoparticle production and it is delivered to the patients for wound healing (Tuberculosis patients) by microencapsulation. The nanoparticles were developed using single emulsion evaporation formed into the microspheres with regular or irregular morphology and the varying size efficiencies and particle size distributions. The microencapsulation of drug with PHB was coated onto the cotton gauze for wound healing. Physical and chemical analysis for he developed cotton gauze for wound healing.

Key words: Poly-beta-hydroxyl-butyrate (PHB) nanoparticles, cotton gauze, drug, tuberculosis.