African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Synthesis, characterization, and anticancer activity against human breast cancer cell-line T47D studies of metal ion Cu(II) complex with 2,4,5-triphenylimidazole ligand

Teguh Hari Sucipto
  • Teguh Hari Sucipto
  • Intitute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia.
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Harsasi Setyawati
  • Harsasi Setyawati
  • Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.
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Irmina Kris Murwani
  • Irmina Kris Murwani
  • Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.
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Fahimah Martak
  • Fahimah Martak
  • Department of Chemistry, Faculty of Natural Science, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia.
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  •  Received: 04 April 2018
  •  Published: 08 October 2018

Abstract

The complex of metal ion Cu(II) with the ligand 2,4,5-trifenilimidazol has been successfully synthesized with mole ratio of metal and ligand 1:2 in N,N-dimethylformamide as a solvent. Complex synthesis results obtained green light crystalline solid. Complex absorbs UV-Vis light at 529 nm. Fourier transform infrared (FTIR) characterization results indicate occurrence of bonding of metals and ligand that is Cu-N in region 422.38 cm-1. Results of elemental analyzer and Atomic Absorption Spectroscopy (AAS) analysis show the complex formed has the formula [Cu(L)2(H2O)2].Cl2. The molecular formula is also supported by the Thermal Gravimetric Analyzer data. Thermal Gravimetric Analyzer (TGA) analysis results showed that there was no water in the crystalline complex compounds. The cytotoxicity test complex compounds made by the method of 3-(4,5-dimetiltiazol-2-yl)-2,5-difeniltetrazolium bromide (MTT) and the IC50 value of complex obtained 72.139 μg/ml.

Key words: Copper(II), 2,4,5-trifenilimidazol, complex compound, characterization, anticancer.