African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Evaluation of saliva levels and therapeutic effects of morinidazole, a new 5-nitroimidazole derivative, in patients with periodontal diseases

Yong-qing Wang*
  • Yong-qing Wang*
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Ya-ning Mei
  • Ya-ning Mei
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Meng Song
  • Meng Song
  • Department of Periodontics, the First Affiliated Hospital with Shanghai Jiao Tong University, China.
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Pei-pei Zhang
  • Pei-pei Zhang
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Ning-ling Jiang
  • Ning-ling Jiang
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Ling Meng
  • Ling Meng
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Ning Ou
  • Ning Ou
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Hai-bo Zhang
  • Hai-bo Zhang
  • Research Division of Clinical Pharmacology, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China, 210029, China.
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Lin Yin
  • Lin Yin
  • Department of Periodontics, the First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, China.
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  •  Received: 17 October 2013
  •  Accepted: 01 July 2014
  •  Published: 15 July 2014

Abstract

The aim of this study was to evaluate and compare the saliva and gingival crevice fluid concentrations, as well as therapeutic effects of morinidazole (MNZ) and ornidazole (ONZ) in patients with periodontitis after intravenous (i.v.) infusion administration. 142 outpatient subjects (80 women and 62 men) were enrolled in the phase II clinical trial, and the patients were randomly assigned to receive intravenous infusions of either Ornidazole or Morinidazole, twice daily for 5 days (500 mg each time, infusion period was 50 min). A saliva was collected prior to and again after finishing the first i.v. dose at intervals of 15, 30, 45, 60, 90 min on day 1. Bacteriological studies were undertaken to determine the effectiveness of the MNZ or ONZ. Reverse phase high performance liquid chromatography (RP-HPLC) method with UV detection at 318 nm was carried out, using a mixture of KH2PO4, acetonitrile and methanol (55:15:30, v/v/v) as a mobile phase, with a flow rate of 1.0 ml/min. There was no significant difference between the MNZ and ONZ groups. The cure rate of morinidazole was found to be slightly higher than that of ONZ, just like the result of concentration in saliva, but no significant differences between the two agents were apparent. During our trial, we found that the clinical resistance of anaerobes to morinidazole was proven to be extremely rare.

 

Key words: Periodontitis, morinidazole, ornidazole, tinidazole, saliva.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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