African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Anti-diabetic activities of Fleurya aestuans (L.) Gaudich in alloxan induced rats

Fagbohun A. B.
  • Fagbohun A. B.
  • Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Fred Jaiyesimi A. A.
  • Fred Jaiyesimi A. A.
  • Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Adegboyega A. A.
  • Adegboyega A. A.
  • Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Kasim L. S.
  • Kasim L. S.
  • Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Kesi C.
  • Kesi C.
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Ndimele B. E.
  • Ndimele B. E.
  • Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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Oluboba M. A.
  • Oluboba M. A.
  • Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
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  •  Received: 06 August 2017
  •  Accepted: 20 September 2017
  •  Published: 25 November 2017

Abstract

Diabetes mellitus is becoming an increasing concern all over the world and such people especially in some communities have used medicinal plants to treat diabetes and its complications. This investigation aimed to examine the hypoglycemic potential of the methanol extract of Fleurya aestuans leaves in normal and alloxan induced diabetic rats. Thirty five Wistar albino rats were grouped into seven different groups of five per group where diabetes was induced in the rats by intra peritoneal administration of alloxan monohydrate (150 mg/kg) except a control group. F. aestuans methanol extract at a dose of 100, 200, 300 and 400 mg/kg of body weight were administered at a single dose per day for a period of 10 days to the diabetic rats, respectively. Five mg/kg of standard drug, glibenclamide (a positive control) was given to one of the groups. The effects of F. aestuans methanol extract of whole plant, on blood glucose was measured in the diabetic rats. This activity is not dose dependent.

 

Key words: Fleurya aestuans leaves, antidiabetic activity, alloxan, glibenclimide, Wistar rats.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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