African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Antioxidant studies of various solvent fractions and chemical constituents of Potentilla evestita Th. Wolf

Abdur Rauf 1, 2*, Rehan Khan3 and Naveed Muhammad4
1Institute of Chemical Sciences, University of Peshawar, Peshawar -25120, KPK, Pakistan. 2Geology Department, University of Peshawar, Peshawar, KPK, Pakistan. 3HEJ Research Institute, Institute of Chemical and Biological sciences, Karachi University Karachi, Pakistan. 4Department of Pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
Email: [email protected]; [email protected]

  •  Accepted: 28 October 2013
  •  Published: 29 October 2013

Abstract

In the present research work acacetin (1), chrysin (2) and umbelliferone (3) were isolated for the first time from the chloroform fraction of Potentilla evestita. The isolated compounds as well as various solvent fractions of the crude ethanolic extract were assessed for their antioxidant potentials. A significant DPPH free radical scavenging effect was observed in the methanolic and chloroform fractions. The acacetic and chrysin demonstrated significant free radical scavenging activity. Likewise compound 3 showed moderate activity as comparative. It was concluded that the therapeutic potential of this plant is due to its antioxidant potential and the antioxidant effect of P. evestita is due to the presence of these three isolated antioxidant compounds.

Key words: Potentilla evestita, acacetin, chrysin, and umbelliferone, antioxidant activity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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