African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

Essien, A. D.
  • Essien, A. D.
  • Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
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Essiet, G. A.
  • Essiet, G. A.
  • Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
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Akuodor, G. C.
  • Akuodor, G. C.
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.
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Akpan, J. L.
  • Akpan, J. L.
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.
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Chilaka, K. C.
  • Chilaka, K. C.
  • Department of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
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Bassey, A. L.
  • Bassey, A. L.
  • Department of Pharmacology and Toxicology, University of Uyo, Nigeria.
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Ezeokpo, B. C.
  • Ezeokpo, B. C.
  • Department of Internal Medicine, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.
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Nwobodo, N. N.
  • Nwobodo, N. N.
  • Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Nigeria.
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  •  Received: 08 October 2015
  •  Accepted: 10 December 2015
  •  Published: 08 February 2016

Abstract

Bombax buonopozense is used in traditional medicine in Nigeria for the treatment of pains and feverish conditions. This study was orally carried out to establish the analgesic, anti-inflammatory and antipyretic properties of an aqueous stem bark extract of Bombax buonopozense in experimental animals. The analgesic activity was measured using the acetic acid-induced abdominal constriction and water tail imgmersion tests. The anti-inflammatory activity was assayed using the xylene and carrageenan-induced oedema tests, while the antipyretic activity was measured using the brewer’s yeast and 2, 4 dinitrophenol-induced pyrexia. The stem bark extract (50, 100 and 200 mg/kg) at all doses used, was found to have significant (P<0.05) analgesic, anti-inflammatory and anti-pyretic activities. Data shows that aqueous stem bark extract of B. buonopozense possesses constituents with therapeutic potential against pains and feverish conditions, thus supporting the use of the stem bark of this plant for similar ailments in traditional medicine.

Key words: Bombax buonopozense, stem bark, aqueous extract, pain, inflammation, fever.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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