African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Verification of pharmaceutical power of generic meropenem vs innovator trough assessment by microbial potency test

Ángela P. Caicedo*
  • Ángela P. Caicedo*
  • Microbióloga Industrial, Biotecnología Ambiental e Industrial. Departamento de Microbiología, Pontificia Universidad Javeriana.
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Sacha T. Fernández
  • Sacha T. Fernández
  • Microbióloga Industrial, Biotecnología Ambiental e Industrial. Departamento de Microbiología, Pontificia Universidad Javeriana.
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Janeth Arias
  • Janeth Arias
  • Bacterióloga, Biotecnología Ambiental e Industrial. Departamento de Microbiología. Pontificia Universidad Javeriana, Carrera 7a. No. 43 ? 82, Ed. 52. Bogotá. Colombia
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Libardo Hernández
  • Libardo Hernández
  • Quimico Farmaceuta, Director Científico Laboratorios Vicar Farmacéutica.
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  •  Received: 02 April 2012
  •  Accepted: 10 June 2014
  •  Published: 08 October 2014

Abstract

 

This study presents the development of a microbiological test method with different microorganisms and different concentrations of antibiotics through "microbial potency," which established the dose-response concentrations and test conditions. The assay method was based on the plate cylinder with the result that there is equivalence between the pharmaceuticals antibiotic such as generic meropenem and innovator for the microorganisms such as Bacillus subtilli ATCC6633, Staphylococcus aureus ATCC 29737, Pseudomonas aeruginosa ATCC 25619 and Escherichia coli ATCC 10536, and pharmaceutical equivalence does not exist between the generic antibiotic meropenem and innovative meronem for Microococcus luteus ATCC 9341.

 

Key words: Microbial power, cylindrical methodin plate, antibiotics, pharmaceutical equivalence, Bacillus subtillis ATCC 6633, Staphylococcus aureus ATCC 29737, Pseudomonas aeruginosa ATCC 25619, Escherichia coli ATCC 10536, Microococcus luteus ATCC 9341.

Abbreviation

WHO/PAHO, World Health Organisation/ Pan American Health Organisation; FDA, Food and Drug Administration; r2, coefficient of determination.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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