Base on the findings from the Research Institute Against Counterfeit drugs (RIACD) and the Organization for Economic Cooperation and Development Drugs (OECD), 700,000 cases of death are recorded per year due to malaria and tuberculosis counterfeit drugs. According to the World Health Organization (WHO), roadside drugs kill at least 100,000 people in Africa every year, 1/3 of these drugs are counterfeit. The objective of this study was to evaluate the quality of paracetamol tablets (500 mg) and ibuprofen (400 mg) sold in an illicit manner within Ndokoti and Douala Central markets In Cameroon. This was an experimental study which was carried out from December, 4th,2013 to June 12th,2014. Samples were randomly selected and The analyzes were focused on the visual, technical and pharmacological tests reported in the International Pharmacopoeia 2018 . Data were analyzed using the Statistical Package for Social Science (SPSS) 20.0 and graphs were mounted using Microsoft excel software. Sampling was done on 39 batches of which 24 were ibuprofen and 15 paracetamols Additionally, out of the 39 batches 53.85 percent came from Ndokoti market and the rest (46.15) were obtained from central market. Visual analysis 25 batches out of the 39 were non-compliant this was estimated at 64.10 percent Also, Hardness testing showed non-compliances at 80 and 91.67 percent for paracetamol and ibuprofen samples respectively. We also observed non-compliances of 33.33 and 12.5 percent for paracetamol and ibuprofen batches respectively at the disintegration test. Finally, the mass uniformity test presented a non-compliance of 8.34% of for ibuprofen. The size measurement showed no noncompliance. All paracetamol tablets were consistent with the dosage. Visual inspection presented nonconformities paracetamol and lots of ibuprofen. This non-compliance was plausible in the central market. 4.