African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Antidiabetic potential of ethanol leaf extract of Bryophyllum pinnatum on alloxan-induced diabetic rats and their haematological profiles

Casmir U. Ezeagu
  • Casmir U. Ezeagu
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria.
  • Google Scholar
Joshua Parker Elijah
  • Joshua Parker Elijah
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria.
  • Google Scholar
Ukegbu Chimere Y
  • Ukegbu Chimere Y
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria.
  • Google Scholar
Eze Chuma S.
  • Eze Chuma S.
  • Department of Applied Biology and Biotechnology Enugu State University of Science and Technology.
  • Google Scholar
Nwodo O. F. C.
  • Nwodo O. F. C.
  • Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria.
  • Google Scholar


  •  Received: 17 August 2017
  •  Accepted: 12 October 2017
  •  Published: 08 November 2017

References

Abei HE (1983). Catalase. In: Methods of Enzymatic Analysis. 3rd edn. 273-285.

 

Albers JJ, Warnick GR, Cheung MC (1978). Dertermination of High Density Lipoprptein. Lipids. 13:926-932.
Crossref

 
 

Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC (1974). Enzymatic determination of serum cholesterol. Clin. chem. 20(4):470-475.

 
 

Assman G, Jab HU, Hormert U (1984). LDL- Cholesterol determination in blood following precipitation of LDL with polyvinyl sulphate. Clin. Chem. Acta. 140(1):77-84
Crossref

 
 

Bucalo G, David H (1973). Quantitative determination of serum triacylglycerol by use of enzymes. Clin. chem. 19(5):476-482.

 
 

Chan TYK (2009). Potential risks associated with the use of herbal anti-obesity products. Drug Safe. 32(6):453-456.
Crossref

 
 

Chattopadhay RF, Bandyopadhay M (2005). Effect of Azadirachta indica leaf extract on serum lipid profile changes in normal and streptozotocin induced diabetic rats. Afr. J. Biomed. Res. 8(2):101-104.

 
 

Cohen-Kohler JC (2007). The morally uncomfortable global drug gap. Clin. Pharmacol. Therap. 84(5): 610-614.
Crossref

 
 

Ei-soud NH, Khalil MY, Oraby FS, Farrag AR (2007). Antidiabetic effects of fenugreek alkaloid extract in streptozotocin induced hypoglycaemic rats. J. Appl. Sci. 3(10):1073-1083.

 
 

Ernst E (2005). The efficacy of herbal medicine-an overview. Fund. Clin.Pharmacol.19(4):405-409.
Crossref

 
 

Gwehenberger B, Rist L, Huch R, Von-Mandach U (2004). Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. Europ. J. Obst. Gynecol. Reprod. Bio. 113(2):164-171.
Crossref

 
 

Harborne JB (1989). Phytochemical methods. A Guide to Modern Technology of Plant Analysis, 3rd Ed. Chapman and Hall, New York. pp. 88-185.

 
 

Khan M, Patil PA, Shobba JC (2004). Influence of Bryophyllum pinnatum leaf extract on wound healing in albino rats. J. Nat. Remedies 4(1):41-46.

 
 

Kulka RG (2006). Cytokinin inhibits epiphyllous plantlet development on leaves of Bryophyllum (Kalanchoë) Marnierianum Exp. Bot. 57(15):4089-4098.
Crossref

 
 

Livingston AL, Whitehand LC, Kohler GO (1997). Microbiological assay for saponin in alfalfa products. J. Asso. Off. Anal. Chem. 60(4):957-958.

 
 

Lorke D (1983). Determination of acute toxicity. Arch. Toxicol. 53:275.
Crossref

 
 

Mahrukh A, Shahid P, Mudasir S, Rajinder R, Pawan KV, Azad AA, Nrip KP (2015). Antidiabetic Effect of Sida Cordifolia (Aqueous Extract) on Diabetes Induced In Wistar Rats Using Streptozotocin And Its Phytochemistry. Int. J. Pharmaceut. Res. Innov. 8, 11-22.

 
 

Muhammad NO, Akolade JO, Usman LA, Oloyede OB (2012). Haematological Parameters of Alloxan-Induced Diabetic Rats Treated With Leaf Essential Oil of Hoslundia Opposita (Vahl). EXCLI J. 11:670-676.

 
 

Ochei J, Kolhatkar A (2005). Medical Laboratory Science: Theory and practice. Tata Mc Graw Hill Publishing Company, New Delhi. pp. 281-283.

 
 

Oyedemi SO, Adewusi EA, Aiyegoro OA, Akinpelu DA (2011). Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic Wistar rats. Asian Pac. J. Trop. Biomed. 1(5):353-358.
Crossref

 
 

Prince SM Menon VP (2000). Hypoglycaemic and other related actions of Tinospora cardifolia roots in alloxan induced diabetic rats. J. Ethnopharmacol. 70(1):9-15.
Crossref

 
 

Satheesh MA, Pari L (2004). Antioxidant effects of Boehavia diffusa in tissues of alloxan-induced diabetic rats. Indian J. Exp. Biol. 42: 669-695.

 
 

Saxena A, Vikram NK (2004). Role of selected Indian plants in the management of type 2 diabetes. J. Alt. Compl. Med. 10(2):369-378.
Crossref

 
 

Selvan VT, Manikandan L, Senthi GP, Suresh R, Kakoti BB, Gomathi P, Kumar DA, Saha P, Gupta M, Mazumder UK (2008) Antidiabetic and Antioxidant Effect of Methanol Extract of Artanema sesamoides in Streptatozocin-Induced Diabetic Rats. Int. J. Appl. Res. Nat. Prod. 1(1):25-33.

 
 

Thirunavukkarasu V, Anuradha CV, Viswanathan P (2003). Protective effect of Fenugreek (Trigonellafoenum graecium) seeds in experimental ethanol toxicity. Phytother. Res. 17(7):737-743.
Crossref

 
 

Ukegbu CY, Odiba A, Edeke A, Anunobi O, Ike C (2016). Anti-diabetic Effect of the Methanolic Leaf Extract of Axonopus compressus (P. Beauv) in Alloxan Induced Diabetic Rats. Int. J. Biochem. Res. Rev. 12(1):1-5.
Crossref

 
 

Wallin B, Rosegren B, Shertzer HG, Caeejo G (1993). Lipoprotein oxidation and measurement of thiobarbituric acid reacting substances, formation in a single microtitre plate: its use for evaluation of antioxidants. Anal. Biochem. 208(1):10-15.
Crossref

 
 

Wieslaw O, Marta J, Anna S (1999). Determination and toxicity of saponins from Amaranthus cruentus seeds. J. Agric. F. Chem. 47: (9) 3685-3687.
Crossref

 
 

World Health Organisation (1996). WHO guidelines for the assessment of herbal medicines. WHO Expert Committee on Specification for Pharmaceutical Preparation. Technical Report series No 863. Geneva.

 
 

Yeung KS, Gubili J, Cassileth B (2008). Evidence-based botanical research: Applications and challenges. Hematol. Oncol. Clin. North Am., 22(4):661-670.
Crossref