African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Antioxidant and antibiofilm activity of Ageratum conyzoides L, and Bidens pilosa L against wound pathogens

Catherine Namuga
  • Catherine Namuga
  • Depatment of Polymer, Textile and Industrial Engineering, Busitema University P. O. Box 256, Tororo, Uganda. 5Department of Mechanical Engineering, Makerere University, College of Engineering, Design, Art, and Technology, P. O. Box 7062, Uganda.
  • Google Scholar
Haruna Muwonge
  • Haruna Muwonge
  • Department of Physiology, Makerere University, College of Health Sciences, P. O. Box 7062, Kampala, Uganda. 3Department of Physiology, Habib Medical School, Islamic University in Uganda (IUIU), P. O. Box 7689, Kampala, Uganda.
  • Google Scholar
Moses Solomon Agwanya
  • Moses Solomon Agwanya
  • Natural Chemotherapeutics Research Institute, Ministry of Health Uganda, P. O. Box 4864, Kampala, Uganda.
  • Google Scholar
Johnbaptist Kirabira
  • Johnbaptist Kirabira
  • Department of Mechanical Engineering, Makerere University, College of Engineering, Design, Art, and Technology, P. O. Box 7062, Uganda.
  • Google Scholar


  •  Received: 12 February 2024
  •  Accepted: 07 March 2024
  •  Published: 30 April 2024

References

Bartolome AP, Villaseñor IM, Yang WC (2013). Bidens pilosa L (Asteraceae): botanical properties, traditional uses, phytochemistry, and pharmacology. Evidence-Based Complementary and Alternative Medicine, 2013. 
Crossref

 

Borges AJ, Saavedra M, Simoes M (2015). Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents. Current Medicinal Chemistry 22(21):2590-2614.
Crossref

 
 

Brandelli CLC, Ribeiro, VB, Zimmer KR, Barth, AL, Tasca T, Macedo AJ (2015). Medicinal plants used by a Mbyá-Guarani tribe against infections: activity on KPC-producing isolates and biofilm-forming bacteria. Natural Product Communications 10(11). 
Crossref

 
 

Catherine N, Haruna M, Margaret L, Nakyejwe J, Tahalu S, John BK (2022). Antibacterial activities of Bidens pilosa L, Hoslundia opposita Vahl, and Ageratum conyzoides L against some common wound pathogens. African Journal of Pharmacy and Pharmacology 16(5):64-78. 
Crossref

 
 

Ciofu O, Tolker-Nielsen T (2019). Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents-how P. aeruginosa can escape antibiotics. Frontiers in Microbiology 10:913. 
Crossref

 
 

Comino-Sanz IM, López-Franco MD, Castro B, Pancorbo-Hidalgo, PL (2021). The role of antioxidants on wound healing: A review of the current evidence. Journal of Clinical Medicine 10(16):3558.
Crossref

 
 

Compaore EO, Edraogo V, Compaore M, Rouamba A, Kiendrebeogo M (2022). Anti-quorum sensing potential of Ageratum conyzoides L (Asteraceae) extracts from Burkina Faso. Journal of Medicinal Plants Research 16(5):174-187. 
Crossref

 
 

Cooper R, Bjarnsholt T, Alhede M (2014). Biofilms in wounds: a review of present knowledge. Journal of Wound Care 23(11):570-582. 
Crossref

 
 

Cushnie TT, Cushnie B, Lamb A J (2014). Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial Agents 44(5):377-386. 
Crossref

 
 

Del Mar Cendra M, Torrents E (2021). Pseudomonas aeruginosa biofilms and their partners in crime. Biotechnology Advances 49:107734. 
Crossref

 
 

Ezeonu CS, Ejikeme CM (2016). Qualitative and quantitative determination of phytochemical contents of indigenous Nigerian softwoods. New Journal of Science, pp. 1-9. 
Crossref

 
 

Farha AK, Yang QQ, Kim G, Li HB, Zhu F, Liu HY, Gan RY, Corke H (2020). Tannins as an alternative to antibiotics. Food Bioscience, 38:100751. 
Crossref

 
 

Gan J, Feng Y, He Z, Li X, Zhang H (2017). Correlations between antioxidant activity and alkaloids and phenols of maca (Lepidium meyenii). Journal of Food Quality 2017. 
Crossref

 
 

Gautam CK, Srivastav AK, Shivendra, B., Madhav M, Shanthi V (2013). An insight into biofilm ecology and its applied aspects. International Journal of Pharmacy and Pharmaceutical Sciences 5:69-73.

 
 

Górniak I, Bartoszewski R, Króliczewski J (2019). Comprehensive review of antimicrobial activities of plant flavonoids. Phytochemistry Reviews 18(1):241-272. 
Crossref

 
 

Kaur S, Mondal P (2014). Study of total phenolic and flavonoid content, antioxidant activity and antimicrobial properties of medicinal plants. Journal of microbiology and experimentation 1(1):00005. 
Crossref

 
 

K?rmusao?lu S (2019). The methods for detection of biofilm and screening antibiofilm activity of agents. Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods pp. 1-17. 
Crossref

 
 

Kou J, Xin TY, McCarron P, Gupta G, Dureja H, Satija S, Mehta M, Bakshi HA, Tambuwala MM, Collet T (2020). Going beyond antibiotics: natural plant extracts as an emergent strategy to combat biofilm-associated infections. Journal of Environmental Pathology, Toxicology and Oncology 39(2)..
Crossref

 
 

Kranjec C, Morales Angeles D, Torrissen Mårli M, Fernández L, García P, Kjos M, Diep DB (2021). Staphylococcal biofilms: Challenges and novel therapeutic perspectives. Antibiotics 10(2):131. 
Crossref

 
 

Lambert P (2002). Mechanisms of antibiotic resistance in Pseudomonas aeruginosa. Journal of the royal society of medicine 95(Suppl 41):22.

 
 

Li J, Zhao X (2020). Effects of quorum sensing on the biofilm formation and viable but non-culturable state. Food Research International 137:109742.
Crossref

 
 

Mani A, Mahalingam G (2017). Effect of anti-biofilm potential of different medicinal plants: Review. Asian Journal of Pharmaceutical and Clinical Research 10(2):24-32.
Crossref

 
 

Mensor L L, Menezes FS, Leitão, GG, Reis AS, Santos TC, Coube CS, Leitão SG (2001). Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytotherapy Research 15(2):127-130.
Crossref

 
 

Merritt JH, Kadouri DE, O'Toole GA (2011). Growing and analyzing static biofilms. Current Protocols in Microbiology 22(1):1B. 1.1-1B. 1.18. 
Crossref

 
 

Okunade AL (2002). Ageratum conyzoides L (asteraceae). Fitoterapia 73(1):1-16. 
Crossref

 
 

Ong KS, Mawang CI, Daniel-Jambun D, Lim YY, Lee SM (2018). Current anti-biofilm strategies and potential of antioxidants in biofilm control. Expert Review of Anti-Infective Therapy 16(11):855-864. 
Crossref

 
 

Oso B, Abey N, Oyeleke O, Olowookere B (2019). Comparative Study of the in vitro Antioxidant Properties of Methanolic Extracts of Chromolaena odorata and Ageratum conyzoides used in Wound Healing. International Annals of Science 6(1):8-12.
Crossref

 
 

Otto M (2018). Staphylococcal Biofilms. Microbiol Spectrum 4:3-0023. 
Crossref

 
 

Pang Z, Raudonis R, Glick BR, Lin TJ, Cheng Z (2019). Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnology Advances 37(1):177-192. 
Crossref

 
 

Percival SL, McCarty SM, Lipsky B (2015). Biofilms and wounds: an overview of the evidence. Advances in Wound Care 4(7):373-381. 
Crossref

 
 

Safari M, Ahmady-Asbchin S (2019). Evaluation of antioxidant and antibacterial activities of methanolic extract of medlar (Mespilus germanica L.) leaves. Biotechnology and Biotechnological Equipment 33(1):372-378. 
Crossref

 
 

Samrot AV, Abubakar Mohamed A, Faradjeva E, Si Jie L, Hooi Sze C, Arif A, Chuan Sean T, Norbert Michael E, Yeok Mun C, Xiao Qi N (2021). Mechanisms and impact of biofilms and targeting of biofilms using bioactive compounds-A review. Medicina 57(8):839. 
Crossref

 
 

Serra R, Grande R, Butrico L, Rossi A, Settimio UF, Caroleo B, Amato B, Gallelli L, De Franciscis S (2015). Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus. Expert Review of Anti-Infective Therapy 13(5):605-613.
Crossref

 
 

Simoes M, Bennett RN, Rosa EA (2009). Understanding antimicrobial activities of phytochemicals against multidrug resistant bacteria and biofilms. Natural prod$uct Reports 26(6):746-757. 
Crossref

 
 

Singh SB, Devi WR, Marina A, Devi WI, Swapana N, Singh CB (2013). Ethnobotany, phytochemistry and pharmacology of Ageratum conyzoides Linn (Asteraceae). Journal of Medicinal Plants Research 7(8):371-385. 

 
 

Song X, Xia Y-X, He Z-D, Zhang H-J (2018). A review of natural products with anti-biofilm activity. Current Organic Chemistry 22(8):789-817. 
Crossref

 
 

Süntar I, Akkol E K, Nahar L, Sarker SD (2012). Wound healing and antioxidant properties: do they coexist in plants? Free Radicals and Antioxidants 2(2):1-7. 
Crossref

 
 

Thi MTT, Wibowo D, Rehm BH (2020). Pseudomonas aeruginosa biofilms. International Journal of Molecular Sciences 21(22):8671. 
Crossref

 
 

Yan Y, Li X, Zhang C, Lv L, Gao B, Li, M (2021). Research progress on antibacterial activities and mechanisms of natural alkaloids: a review. Antibiotics 10(3):318. 
Crossref