African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

Nwachukwu Daniel C.
  • Nwachukwu Daniel C.
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Aneke Eddy I
  • Aneke Eddy I
  • Department of Medicine, Enugu State University Teaching Hospital, Enugu, Nigeria.
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Nwachukwu Nkiru Z.
  • Nwachukwu Nkiru Z.
  • Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Nigeria.
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Azubike Nkiru
  • Azubike Nkiru
  • Department of Medical Laboratory Science, University of Nigeria, Enugu Campus.
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Obika Leonard F. O.
  • Obika Leonard F. O.
  • Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria.
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  •  Received: 08 February 2016
  •  Accepted: 13 April 2016
  •  Published: 15 May 2016

References

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Felgendreger LA, Fluharty SJ, Yee DK, Flanagan-Cato LM (2012). Endogenous angiotensin II-induced p44/42 MAPK activation mediates sodium appetite but not thirst or neurohypophysial secretion in male rats. J. Neuroendocrinol. 25(2):97.
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Gordon MS, Majzoub JA, Williams GH, Gordon MB (1997). Sodium balance modulates thirst in normal man. Endocrinol. Res. 23(4):377-92.
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Herrera‑Arellano A, Flores‑Romero S, Chavez‑Soto MA, Tortoriello J (2004). Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: A controlled and randomized clinical trial. Phytomedicine 11:375‑82.
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Jonadet M, Bastide J, Boyer B, Carnat AP, Lamaison JL (1980). In vitro enzyme inhibitory and in vivo cardioprotective activities of Hibiscus (Hibiscus Sabdariffa L.). Pharm. Belg. 45:120-1214.

 
 

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McKinley MJ, Johnson AK (2004). The Physiological Regulation of Thirst and Fluid. News Physiol. Sci. 19(1):1-6.
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Nwachukwu DC, Aneke EI, Obika LFO, Nwachukwu NZ (2015a). Investigation of Antihypertensive Effectiveness and Tolerability of Hibiscus sabdariffa in Mild to Moderate Hypertensive Subjects in Enugu, South-east, Nigeria. Am. J. Phytomed. Clin. Ther. 3(4):339-345.

 
 

Nwachukwu DC, Aneke EI, Obika LF, Nwachukwu NZ (2015b). Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensinaldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J. Pharmacol. 47:540-5.
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Rasmussen MS, Simonsen JA, Sandgaard NC, Høilund-Carlsen PF, Bie P (2003). Mechanisms of acute natriuresis in normal humans on low sodium diet. J Physiol. 3:15, 546(Pt 2):591-603.

 
 

Robertson GI (1991). Disorder of thirst in man. In: thirst physiology and psychological aspects (Eds: Ramsay DJ Broth DA), Springer Verlag, London. pp. 453-477.
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Robertson GL (1984). Abnormality of Thirst Regulation. Kidney Int. 25:460-469.
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Rolls BJ, Wood RJ, Roll ET, Lind H, Lind W, Ledingham JGG (1980). Thirst Following Water Deprivation in Humans. Am. J. Physiol. 239:R476-R482.

 
 

Shailendra KT, Bhanu PM, Ruchi T, Manish M, Kamlakar T (2011). Serum and urinary electrolytes level in the subjects of two different environmental conditions. J. Stress Physiol. Biochem. 7(1):20-26.

 
 

Stachenfeld NS (2008). Acute Effects of Sodium Ingestion on Thirst and Cardiovascular Function. Curr. Sports Med. Rep. 7(4Suppl):S7-13.
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Sufit E, Houpt KA, Sweeting M (1985). Physiological stimuli of thirst and drinking patterns in ponies. Equine Vet. J. 17(1):12-6.
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Thompson DA, Campbell RG (1977). Hunger In Humans, Induced By 2-Deoxy- Glucose: Glucoprivic Control Of Taste Preference And Food Intake. Science 198:1065-1068.
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Verbalis JG (2007). How does brain sense osmolality? J. Am. Soc. Nephrol. 18(12):3056-3059.
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WHO/ISH (1999/2003). Statement on Hypertension. Management of Hypertension. J. Hypertens. 17:151-183.