African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Full Length Research Paper

Development and validation of high sensitive UHPLC-ESI-MS assay for simultaneous determination of dextromethorphan, dextrorphan, and midazolam in human plasma

Naser L. Rezk
  • Naser L. Rezk
  • Department of Clinical Laboratory Sciences, Applied Medical Sciences, Taibah University, KSA, Saudi Arabia.
  • Google Scholar
Saber M. Eweda
  • Saber M. Eweda
  • Department of Clinical Laboratory Sciences, Applied Medical Sciences, Taibah University, KSA, Saudi Arabia.
  • Google Scholar
Loay Kasahkary
  • Loay Kasahkary
  • Almadinah Toxicology Center, Health Ministry, KSA, Saudi Arabia.
  • Google Scholar
Omar A. Rezk
  • Omar A. Rezk
  • Department of Nutrition, Gilling’s School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
  • Google Scholar
Muzaffar Iqbal
  • Muzaffar Iqbal
  • Department of Pharmaceutical Chemistry, College of Pharmacy, Kind Saud University, Riyadh, KSA, Saudi Arabia.
  • Google Scholar


  •  Received: 26 December 2017
  •  Accepted: 05 February 2018
  •  Published: 08 February 2018

References

Aebi B, Sturny-Jungo R, Bernhard W, Blanke R, Hirsch R (2002). Quantitation using GC-TOF-MS: example of Bromazepam, Forensic Sci. Int. 128(1-2):84-89.
Crossref

 

Bugey B, Staub C (2004). Rapid analysis of Benzodiazepines in whole blood by high-performance liquid chromatography: use of a monolithic column. J. Pharm. Biomed. Anal. 35(3):555-562.
Crossref

 

Chyka PA, Erdman AR, Manoguerra AS, Christianson G, Booze LL, Nelson LS, Woolf AD, Cobaugh DJ, Caravati EM, Scharman EJ, Troutman WG (2007). American Association of Poison Control Centers. Dextromethorphan poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin. Toxicol. (Phila). 45(6):662-772.
Crossref

 

Cook JM, Marshall R, Masci C, Coyne JC (2007). Physicians' perspectives on prescribing Benzodiazepines for older adults: A qualitative study. J. Gen. Intern. Med. 22:303-307.
Crossref

 

El Mahjoub A, Staub C (2000). High-performance liquid chromatographic method for the determination of benzodiazepines in plasma or serum using the column-switching technique. J. Chromatogr. B: Biomedical Sci. Appl. 742(2):381-390.
Crossref

 

Ferslew KE, Hagardorn AN, McCormick WF (1989), Postmortem determination of the biological distribution of Sufentanil and Midazolam after an acute intoxication. J. Forensic Sci. 34:249-257.
Crossref

 

Food and Drug Administration (2001). Guidance for Industry, Bioanalytical Method Validation, 

 

Fuhr U, Jetter A, Kirchheiner J (2007). Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach. Clin. Pharmacol. Ther. 81(2):270-83.
Crossref

 

Moore C, Coulter C, Crompton K (2007). Determination of Benzodiazepines in Urine and Blood Using Rapid Resolution Liquid Chromatography/Triple Quadrupole Mass Spectrometry. Agilent Technologie, Immunalysis Corporation, Pomona, CA 5989-7201.

 

Nordt S, Clark RJ (1997). Midazolam: a review of therapeutic uses and toxicity. J. Emerg. Med. 15(3):357-365.
Crossref

 

Rang HP, Dale MM, Ritter JM, Flower R (2007). Rang and Dale's Pharmacology (6th ed.) Elsevier health pp. 535-542.

 

Samanidou VF, Pechlivanidou AP, Papadoyannis IN (2007). Development of a validated HPLC method for the determination of four 1,4-Benzodiazepines in human biological fluids. J. Sep. Sci. 30(5):87-679.
Crossref

 

Shenkman Z, Ornstein E, Adler D (1995). Drug overdose as a consequence of misuse of a syringe pump Anesth. Analg. 81(3):652-653.

 

Trevor AJ, Katzung BG, Masters S, Knuidering-Hall M (2007). Masters, Katzung and Trevor's Pharmacology (8th ed.), Mc graw-Hill, Boston.

 

Unger KA, Watterson JH (2016). Analysis of Dextromethorphan and Dextrorphan in Skeletal Remains Following Decomposition in Different Microclimate Conditions, J. Anal. Toxicol. 40(8):669-676.
Crossref

 

Yang Y, Yu J, Lu Y, Xia Y, Zhong D, Chen X (2013). High-sensitivity liquid chromatography-tandem mass spectrometry method for the simultaneous determination of sodium picosulfate and its three major metabolites in human plasma. J. Chromatogr. B. 915:1-7.
Crossref

 

Zevzikoviene A, Zevzikovas A, Bertulis A (2003). Determination of diazepine derivatives: Alprazolam, medazepam, chlordiaze-poxid mixture by high performance liquid chromatography, Medicina (Kaunas) 39(2):37-41.