African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl ("jangadeira")

Edla Julinda Ribeiro Coutinho Espinola Guedes
  • Edla Julinda Ribeiro Coutinho Espinola Guedes
  • Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba, Brazil.
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Josué do Amaral Ramalho
  • Josué do Amaral Ramalho
  • Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba, Brazil.
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Luciana da Silva Nunes Ramalho
  • Luciana da Silva Nunes Ramalho
  • Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba, Brazil.
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Gilson Espínola Guedes Neto
  • Gilson Espínola Guedes Neto
  • Program in Drug Development and Technological Innovation, Health Sciences Center, Federal University of Paraíba, Brazil.
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Andressa Brito Lira
  • Andressa Brito Lira
  • Program in Drug Development and Technological Innovation, Health Sciences Center, Federal University of Paraíba, Brazil.
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Mateus Feitosa Alves
  • Mateus Feitosa Alves
  • Scientific Initiation Student, Federal University of Paraíba, Brazil.
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Guilherme Eduardo Nunes Dias
  • Guilherme Eduardo Nunes Dias
  • Scientific Initiation Student, Federal University of Paraíba, Brazil.
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Yanna Carolina Fereira Teles
  • Yanna Carolina Fereira Teles
  • Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba, Brazil.
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Caliandra Maria Bezerra Luna Lima
  • Caliandra Maria Bezerra Luna Lima
  • Department of Physiology and Pathology, Health Sciences Center, Federal University of Paraíba, Brazil.
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Maria de Fátima Vanderlei Souza
  • Maria de Fátima Vanderlei Souza
  • Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Brazil.
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Margareth de Fátima Formiga Melo Diniz
  • Margareth de Fátima Formiga Melo Diniz
  • Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Brazil.
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Reinaldo Nóbrega de Almeida
  • Reinaldo Nóbrega de Almeida
  • Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Brazil.
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  •  Received: 06 November 2015
  •  Accepted: 10 December 2015
  •  Published: 29 January 2016

References

Almeida RN, Falcão ACGM, Diniz RST, QUINTANS-JÚNIOR LJ, POLARI RM, Barbosa-Filho, JM, Agra MF, Duarte JC, Ferreira CD, Antoniolli AR, Araújo CC (1999) Metodologia para avaliação de plantas com atividade no Sistema Nervoso Central e alguns dados experimentais. Rev. Br. Pharm. 80:72-76.
 

Bakoma B, Berke B, Eklu-Gadegbeku K, Agbonon A, Aklikokou K, Gbeassor M, Creppy EE, Moore N (2013). Acute and sub-chronic (28 days) oral toxicity evaluation of hydroethanolic extract of Bridelia ferruginea Benth root bark in male rodent animals. Food Chem. Toxicol. 52:176-179.
Crossref

  
 

Barros SBM, Davino SC (2003). "Avaliação da toxicidade". In Seizi, O. "Fundamentos da toxicologia". 2nd ed.:, São Paulo: Atheneu. 59-67.

  
 

Billerter M, Meier B, Sticher O (1991). 8-hydroxyflavonoid glucuronides from Malva sylvestris. Phytochemistry 30(3):987-990.
Crossref

  
 

Brasil, Resolução-RE Nº 90, de 16 de março de (2004). Guia para realização de estudos de toxicidade pré-clínica de fitoterápicos." 

  
 

Castello Branco ACS, Diniz MDFFM, Almeida RN, Santos HB, Oliveira KM, Ramalho JA, Dantas JG (2011). Parâmetros bioquímicos e hematológicos de ratos Wistar e camundongos Swiss do Biotério Professor Thomas George. Revista Brasileira de Ciências da Saúde. 15(2):209-214.
Crossref

  
 

Fryxell PA (1997). The american genera of Malvaceae-II. Brittonia 9(2):204-269.
Crossref

  
 

Henry JB (2008). Diagnósticos Clínicos e tratamento por métodos laboratoriais. 20a ed: 1670. São Paulo, Manole.

  
 

Husna RN, Noriham A, Nooraain H, Azizah AH, Amna OF (2013). Acute oral tocixity effects of Momordica charantia in sprague dawley rats. Int. J. Biosci. Biochem. Bioinform. 3(4):408-410.

  
 

Nakatani M, Fukunaga Y, Hase T (1986). Aliphatic compounds from Hybiscus rosa-sinensis. Phytochemistry 25(2):449-452.
Crossref

  
 

Ravel R (1997). Laboratório Clínico: Aplicações clínicas dos achados laboratoriais. 6. ed. Rio de Janeiro: Guanabara-Koogan.

  
 

Sadeghi H, Hajhashemi V, Minaiyan M, Movahedian A, Talebi A (2011). A study on the mechanisms involving the anti-inflammatory effect of amitriptyline in carrageenan-induced paw edema in rats. Eur. J. Pharmacol. 667(1-3):396-401.
Crossref

  
 

Schultz AR (1968). Introdução ao estudo da botânica sistemática. 3 ed: 241. Porto Alegre: Ed.Globo.

  
 

Sharma PV, Ahmad ZA (1989). Two sesquiterpene lactones from Abutilon indicum. Phytochemistry 28(12):3525.
Crossref

  
 

Silva DA, Silva TMS, Lins ACS, Costa DA, Cavalcante JMS, Matias WN, Souza MFV (2006).Chemical constituents and antioxidant activity of Sida galheirensis Ulbr. (Malvaceae). Quim Nova 29(6):1250-1254.
Crossref

  
 

Silva, DA, Falcão-Silva VS, Gomes AYS, Costa, DA, Lemos VS, Agra MF, Braz-Filho R, Siqueira-Junior JP, Souza MFV (2009). Triterpenes and phenolic compounds isolated from the aerial parts of Herissantia tiubae and evaluation of 5,4',-dihydroxy-3,6,7,8,3'- pentamethoxyflavone as a modulator of bacterial drug resistance. Pharm. Biol. 47(4):279-284.
Crossref

  
 

Stevens KR, Mylecraine L (1994). Issues in chronictoxicology. In: Haves AW (Ed), Principles and methods of toxicology, 3 ed: 673 New York: Raven Press.

  
 

Teles YCF, Ribeiro-filho J, Bozza PT, Agra MF, Siheri W, Igoli JO, Gray AI, Souza MFV (2014). Phytochemical investigation of Wissadula periplocifolia (L.) C. Presl and evaluation of its antibacterial activity. Química nova 37(9):1491-1495.

  
 

Veiga-junior VF, Pinto AC, Maciel MAM (2005). Plantas medicinais: cura segura? Quimica Nova 2(3):519-528.
Crossref

  
 

Venkatesh S, Reddy, YSR, Suresh B, Reddy BM, Ramesh M (1999). Antinociceptive and anti-inflammatory activity of Sida rhomboidea leaves. J. Ethnopharm. 67(2):229-232.
Crossref

  
 

Williams HJ, Sattler I, Moyna G, Scott AI, Bell AA, Vinson SB (1995). Diversity in cyclic sesquiterpene production by Gossypium hirsutum. Phytochemistry 40(6):1633-1636.
Crossref

  
 

Winter CA, Risley EA, Nuss GW (1962). Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 111:544-547.
Crossref

  

 

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