African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2285

Review

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Sutapa Biswas Majee
  • Sutapa Biswas Majee
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Dhruti Avlani
  • Dhruti Avlani
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Priyanka Ghosh
  • Priyanka Ghosh
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar
Gopa Roy Biswas
  • Gopa Roy Biswas
  • Division of Pharmaceutics, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata-Group of Institutions, 124 B.L. Saha Road, Kolkata 700053, India.
  • Google Scholar


  •  Received: 14 November 2017
  •  Accepted: 27 December 2017
  •  Published: 08 January 2018

References

Aguilar-Brise-o JA, Cruz-Suarez LE, Sassi JF, Ricque-Marie D, Zapata-Benavides P, Mendoza-Gamboa E, Rodríguez-Padilla C, Trejo-Avila LM (2015). Sulphated polysaccharides from Ulvaclathrata and Cladosiphonokamuranus seaweeds both inhibit viral attachment/entry and cell-cell fusion, in NDV infection. Mar. Drugs. 13:697-712.
Crossref

 

Ale MT, Mikkelsen JD, Meyer AS (2011). Important determinants for fucoidan bioactivity: a critical review of structure-function relations and extraction methods for fucose-containing sulfated polysaccharides from brown seaweeds. Mar. Drugs. 9:2106-2130.
Crossref

 
 

Alves A, Sousa RA, Reis RL (2013). cytotoxicity assessment of ulvan, a polysaccharide extracted from green algae. Phytother. Res. 27(8):1143-1148.
Crossref

 
 

Atashrazm F, Lowenthal RM, Woods GM, Holloway AF, Dickinson JL (2015). Fucoidan and cancer: A multifunctional molecule with anti-tumor potential. Mar. Drugs. 13:2327-2346.
Crossref

 
 

Ates O (2015).Systems biology of microbial exopolysaccharides production. Front. Bioeng. Biotechnol. 3:200.
Crossref

 
 

Bahrami B, Mohammadnia-Afrouzi M, Bakhshaei P, Yazdani Y, Ghalamfarsa G, Yousefi M, Sadreddini S, Jadidi-Niaragh F, Hojjat- Farsangi M (2015). Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy. Tumor Biol. 36:5727-5742.
Crossref

 
 

Berteau O, Mulloy B (2003). Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13(6):29R-40R.
Crossref

 
 

Bobin-Dubigeon C, Lahaye M, Guillon F, Barry J, Gallant DJ (1997). Factors limiting the biodegradation of Ulva sp cell-wall polysaccharides. J. Sci. Food Agric. 75:341-351.
Crossref

 
 

Cherian RS, Sreejith R, Syama S, Sruthi S, Gayathri V, Maekawa T, Sakthikumar D, Mohanan PV (2014). Evaluation of toxicity of maura reduced graphene oxide using in vitro systems. J. Nanomed. Nanotechnol. 5:200.

 
 

Collen P, Jeudy A, Sassi JF, Groisillier A, Czjzek M, Coutinho PM, Helbert W (2014). A novel unsaturated β-glucuronyl hydrolase involved in ulvan degradation unveils the versatility of stereochemistry requirements in family GH105. J. Biol. Chem. 289:6199-6211.
Crossref

 
 

Collén PN, Sassi JF, Rogniaux H, Marfaing H, Helbert W (2011). Ulvan lyases isolated from the Flavobacteria Persicivirga ulvanivorans are the first members of a new polysaccharide lyase family. J. Biol. Chem. 286:42063-42071.
Crossref

 
 

Cunha L, Grenha A (2016). Sulfated seaweed polysaccharides as multifunctional materials in drug delivery applications. Mar. Drugs. 14:42.
Crossref

 
 

Durand M, Beaumatin P, Bulman B, Bemalier A, Grivet JP, Serezat M, Gramet G, Lahaye M (1997). Fermentation of green alga sealettuce (Ulva sp) and metabolism of its sulphate by human colonic microbiota in a semi-continuous culture system. Reprod. Nutr. Dev. 37(3):267-283.
Crossref

 
 

Felisilda BMB, de Eulate EA, Stringer DN, Fitton JH, Arrigan DWM (2017). Electrochemical behaviour at a liquid-organogel microinterface array of fucoidan extracted from algae. Analyst 142(17):3194-3202.
Crossref

 
 

Fernández-Díaz C, Coste O, Malta EJ (2017). Polymer chitosan nanoparticles functionalized with Ulva ohnoi extracts boost in vitro ulvanimmunostimulant effect in Solea senegalensis macrophages. Algal Res. 26:135-142.
Crossref

 
 

Garron M, Cygler M (2014). Uronic polysaccharide degrading enzymes. Curr. Opin. Struct. Biol. 28:87-95.
Crossref

 
 

He C, Muramatsu H, Kato S, Ohnishi K (2017). Characterization of an Alteromonas long-type ulvan lyase involved in the degradation of ulvan extracted from Ulva ohnoi. Biosci. Biotechnol. Biochem. :1-7.
Crossref

 
 

Hemsworth GL, De´ Jean G, Davies GJ, Brumer H (2016). Learning from microbial strategies for polysaccharide degradation. Biochem. Soc. Trans. 44:94-108.
Crossref

 
 

Ikeguchi M, YamamotoM, Arai Y, Maeta Y, Ashida K, Katano K, Miki Y, Kimura T (2011). Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer. Onc. Lett. 2:319-322.
Crossref

 
 

Kimura R, Rokkaku T, Takeda S, Senba M, Mori N (2013). Cytotoxic effects of fucoidan nanoparticles against osteosarcoma. Mar. Drugs. 11:4267-4278.
Crossref

 
 

Majee SB, Avlani D, Biswas GR (2017a). Pharmacological, pharmaceutical, cosmetic and diagnostic applications of sulfated polysaccharides from marine algae and bacteria. Afr. J. Pharm. Pharmacol. 11:68-77.
Crossref

 
 

Majee SB, Avlani D, Biswas GR (2017b). Rheological behavior and pharmaceutical applications of bacterial exopolysaccharides. J. Appl. Pharm. Sci. 7:224-232.

 
 

Manivasagan P, Bharathiraja S, Moorthy MS, Oh Y, Song K, Seo H, Oh J (2017). Anti-EGFR antibody conjugation of fucoidan-coated gold nanorods as novel photothermal ablation agents for cancer therapy. ACS Appl. Mater. Interf. 9:14633-14646.
Crossref

 
 

Mathew L, Burney M, Gaikwad A, Nyshadham P, Nugent E, Gonzalez A, Smith J (2016). Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment. Integr. Cancer Ther. 16:1-13.

 
 

Melcher R, Neumann M, Pablo J, Werner F, Gröhn F, Moerschbacher B (2017). Revised domain structure of ulvan lyase and characterization of the first ulvan binding domain. Sci. Rep. 7:1-9.
Crossref

 
 

Nagamine T, Nakazato K, Tomioka S, Iha M, Nakajima K (2015). Intestinal absorption of fucoidan extracted from the brown seaweed, Cladosiphono kamuranus. Mar. Drugs. 13:48-64.
Crossref

 
 

Ohshiro T, Ohmoto Y, Ono Y, Ohkita R, Miki Y, Kawamoto H, Izumi Y (2010). Isolation and characterization of a novel fucoidan-degrading microorganism. Biosci. Biotechnol. Biochem. 74:1729-1732. Biotechnol. 35(3):410-424.

 
 

Popa EG, Reis RL, Gomes ME (2015). Seaweed polysaccharide-based hydrogels used for the regeneration of articular cartilage. Crit. Rev.
Crossref

 
 

Posocco B, Dreussi E, de Santa J, Toffoli G, Abrami M, Musiani F, Grassi M, Farra R, Tonon F, Grassi G, Dapas B (2015). Polysaccharides for the delivery of antitumor drugs. Materials 8:2569-2615.
Crossref

 
 

Qianqian W, Shuang M, Hourong X, Min Z, Jingmin C (2011). Purification and the secondary structure of fucoidanase from Fusarium sp. LD8. Evid-Based Complement. Altern. Med. Article ID 196190. 8p.

 
 

Raposo MF, Bernardo de Morais A, Costa de Morais RM (2016). Emergent sources of prebiotics: seaweeds and microalgae. Mar. Drugs. 14:27.
Crossref

 
 

Raveendran S, Dhandayuthapani B, Nagaoka Y, Yoshida Y, Maekawa T, Kumar DS (2013). Biocompatible nanofibers based on extremophilic bacterial polysaccharide, mauran from Halomonas maura. Carbo. Polym. 92:1225-1233.
Crossref

 
 

Raveendran S, Girija AR, Balasubramanian S, Ukai T, Yoshida Y, Maekawa T, Kumar DS (2014). Green approach for augmenting biocompatibility to quantum dots by extremophilic polysaccharide conjugation and nontoxic bioimaging. ACS Sustain. Chem. Eng. 2:1551-1558.
Crossref

 
 

Raveendran S, Palaninathan V, Nagaoka Y, Fukuda T, Iwai S, Higashi T, Mizuki T, Sakamoto Y, Mohanan PV, Maekawa T, Kumar DS (2015). Extremophilic polysaccharide nanoparticles for cancer nanotherapyand evaluation of antioxidant properties. Int. J. Biol. Macromol. 76:310-319.
Crossref

 
 

Raveendran S, Rochani AK, Maekawa T, Kumar S (2017). Smart Carriers and Nanohealers: A nanomedical insight on natural polymers. Materials 10:929.
Crossref

 
 

Rehm BHA (2009). Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives. Horizon Scientific Press.

 
 

Robic A, Sassi JF, Lahaye M (2008). Impact of stabilization treatments of the green seaweed Ulvarotundata (Chlorophyta) on the extraction yield, the physico-chemical and rheological properties of ulvan. Carbohydr. Polym. 74:344-352.
Crossref

 
 

Rouzet F, Bachelet-Violette L, Alsac J, Suzuki M, Meulemans A, Louedec L, Petiet A, Jandrot-Perrus M, Chaubet F, Michel J, Guludec D, Letourneur D (2011). Radiolabeled fucoidan as a p-selectin targeting agent for in vivo imaging of platelet-rich thrombus and endothelial activation. J. Nucl. Med. 52:1433-1440.
Crossref

 
 

Rujitanaroj P, Launais R, Chew SY, Visage C (2014). Polysaccharide electrospun fibers with sulfated poly(fucose) promote endothelial cell migration and VEGF-mediated angiogenesis. Biomater. Sci. 2(6):843-852.
Crossref

 
 

Rydahl MG, Kracun SK, Fangel JU, Miche G, Guillouzo A, Génicot S, Mravec J, Harholt J, Wilkens C, Motawia MS, Svensson M, Tranquet O, Ralet M, Jørgensen B, Domozych DS, Willats W (2017). Development of novel monoclonal antibodies against starch and ulvan - implications for antibody production against polysaccharides with limited immunogenicity. Sci. Rep. 7:1-13.
Crossref

 
 

Salek K, Gutierrez T (2016). Surface-active biopolymers from marine bacteria for potential biotechnological applications. AIMS Microbiol. 2:92-107.
Crossref

 
 

Silchenko AS, Kusaykin MI, Kurilenko VV, Zakharenko AM, Isakov VV, Zaporozhets TS, Gazha AK, Zvyagintseva TN (2013). Hydrolysis of fucoidan by fucoidanase isolated from the marine bacterium, Formosa algae. Mar. Drugs. 11:2413-2430.
Crossref

 
 

Silva M, Vieira L, Almeida AP, Kijjoa A (2013). The marine macroalgae of the genus Ulva: Chemistry, biological activities and potential applications. Oceanography 1:1-6.

 
 

Srivastava P, Kowshik M (2015) Biosynthesis of nanoparticles from halophiles. in: Maheshwari D, Saraf M. (eds) Halophiles. Sustainable Development and Biodiversity, Vol 6. Springer, Cham.
Crossref

 
 

Steen AD, Ziervogel K, Ghobrial S, Arnosti C (2012). Functional variation among polysaccharide-hydrolyzing microbial communities in the Gulf of Mexico. Mar. Chem. 138:13-20.
Crossref

 
 

Suzuki M, Bachelet-Violette L, Rouzet F, Beilvert A, Autret G, Maire M, Menager C, Louedec L, Choqueux C, Saboural P, Haddad O, Chauvierre C, Chaubet F, Michel J, Serfaty J, Letourneur D (2014). Ultra small superparamagnetic iron oxide nanoparticles coated with fucoidan for molecular MRI of intraluminal thrombus. Nanomed. 10:73-87.
Crossref

 
 

Taboada C, Mill’an R. M’ıguez I (2010). Composition, nutritional aspects and effect on serum parameters ofmarine algae Ulvarigida. Sci. Food Agric. 90:445-449.

 
 

Thuy TTT, Quach TMT, Nguyen TN, Luong DV, Bui ML, Tran TTV (2016). Structure and cytotoxic activity of ulvan extracted from green seaweed Ulva lactuca. Int. J. Biol. Macromol. 93:695-702.
Crossref

 
 

Ulaganathan TS, Boniecki MT, Foran E, Buravenkov V, Mizrachi N, Banin E, Helbert W, Cygler M (2017). New ulvan-degrading polysaccharide lyase family: structure and catalytic mechanism suggests convergent evolution of active site architecture. ACS Chem. Biol. 12:1269-1280.
Crossref

 
 

Venkatesan J, Anil S, Kim S, Shim M (2016). Seaweed polysaccharide-based nanoparticles : Preparation and applications for drug delivery. Polymers 8:30.
Crossref

 
 

Wells ML, Potin P, Craigie JS, Raven JA, Merchant SS, Helliwell KE, Smith AG, Camire ME, Brawley SH (2017). Algae as nutritional and functional food sources: revisiting our understanding. J. Appl. Phycol. 29:949-982.
Crossref

 
 

Yoshimura T, Hirao N, Fujioka R (2016). Preparation and characterization of biodegradable hydrogels based on ulvan, a polysaccharide from green seaweeds. Pol. Renew. Resour. 7:33-41.