Full Length Research Paper
Abstract
The sensitivity of liver to chemotherapy provides the basis of novel investigational treatment. An amino thienoandrostane derivative was synthesized and tested in vitro for anti-tumor activity against heapto-ma cell lines (HepG2) using MTT assay. Also the in vivo anti-tumor activity was evaluated against Ehrlich ascites carcinoma (EAC). After 24 h of tumor inoculation, the tested compound was adminis-tered intraperitoneal (i.p.) with concentration of 25 mg/kg day after day for 14 days. The effect of amino-thienoandrostane on the growth of transplantable tumor and simultaneous alterations in hematological profile was estimated. Aminothienoandrostane in olive oil induced significantly high cytotoxic effect against HepG2cell line (IC50 = 36). Aminothienoandrostane completely inhibited tumor growth and maintained the hemoglobin content, body weight, and WBCs near normal values and similar to what obtained for standard drug 5-flurouracil which is one of the most commonly used drugs to treat cancers.
Key words: Anti-cancer, androstane, hepatoma (Hep-G2), Ehrlich ascites carcinoma(EAC), cytotoxicity.
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