International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Torsade de pointes in a patient with bronchopenumonia and atrial fibrillation treated with clarithromycin

Lihua Fang
  • Lihua Fang
  • Department of Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
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Chung-Jen Huang
  • Chung-Jen Huang
  • Division of Pulmonary Medicine and Intensive Care Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
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Hwang-Daw Hua
  • Hwang-Daw Hua
  • Division of Cardiology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
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Chung-Hsin Huang
  • Chung-Hsin Huang
  • Department of Anesthesiology, Mackay Memorial Hospital, Hsinchu, Taiwan.
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  •  Accepted: 22 July 2009
  •  Published: 30 August 2009

Abstract

Clarithromycin is a macrolide antibiotic widely used in pulmonary infection and Helicobacter pylori eradication. QT prolongation on an electrocardiogram with torsade de pointes is an uncommon fatal side effect. We report a patient with atrial fibrillation and congestive heart failure who develops torsade de pointes after clarithromycin, tamoxifen, amoxillin/clavulanate, digoxin and verapamil use, and discuss the pharmacological mechanism and prevention.

Key words: Torsade de pointes, clarithromycin, atrial fibrillation, QT interval.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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