International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Case Report

Methotrexate-induced toxic epidermal necrolysis: a case report

I. Tazi
  • I. Tazi
  • Hematology and Pediatric Oncology, Hopital 20 Aout 1953 Casablanca Morocco
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A. Madani, S. Zafad
  • A. Madani, S. Zafad
  • Hematology and Pediatric Oncology, Hopital 20 Aout 1953 Casablanca Morocco
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M. Harif, A. Quessar
  • M. Harif, A. Quessar
  • Hematology and Pediatric Oncology, Hopital 20 Aout 1953 Casablanca Morocco
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S. Benchekroun
  • S. Benchekroun
  • Hematology and Pediatric Oncology, Hopital 20 Aout 1953 Casablanca Morocco
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  •  Accepted: 27 March 2009
  •  Published: 30 April 2009

Abstract

Methotrexate (MTX) is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase resulting in decreased cell levels of tetrahydrofolate. Adverse cutaneous reactions to MTX are usually dose-related and have been mainly reported in patients receiving extremely large doses of chemotherapy. Toxicity can affect multiple organ systems including bone marrow, liver, intestinal tract, kidneys, lungs, skin, and blood vessels, resulting in death in severe cases. In this report we describe the case of a 9 year old boy who developed toxic epidermal necrolysis after high-dose MTX treatment and discuss the important clinical and therapeutic features of this condition.

Key words: Methotrexate, skin, toxicity, necrolysis

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This article is published under the terms of the Creative Commons Attribution License 4.0

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