International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 128

Full Length Research Paper

Antagonistic salubrious effects of Tahitian Noni in Momordica charantia-induced cytoarchitectural alterations in rat testes: Parallel light microscopic findings

Yama O. E.
  • Yama O. E.
  • Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria,
  • Search for this author on:
  • Google Scholar
Bassey R. B.
  • Bassey R. B.
  • Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Nigeria.
  • Search for this author on:
  • Google Scholar
Amah C. I.
  • Amah C. I.
  • Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria,
  • Search for this author on:
  • Google Scholar
Oyebadejo S. A.
  • Oyebadejo S. A.
  • Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria,
  • Search for this author on:
  • Google Scholar
Oremosu A. A.
  • Oremosu A. A.
  • Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria,
  • Search for this author on:
  • Google Scholar


  •  Accepted: 10 November 2011
  •  Published: 28 February 2012

Abstract

Drug interaction is a situation in which a substance affect the activity of another to either increased or decreased its outcome. It could also produce an entirely new effect. To determine if addition of Tahitian Noni dietary supplement can alleviate Momordica charantia-induced testicular alterations in Sprague-Dawley rats. Thirty adult male 16 - 20 weeks’ old Sprague-Dawley rats randomized into 6 groups (n=5) were used. Group I (DW8wk) the control: administered distilled water for 8 weeks. Group II (MC50 (8wk)): received 50 mg/100 g b.w. of M. charantia seed extracts for 8 weeks. Group III (MC50 (4wk)-N5 (4wk)): gavaged 50 mg/100 g b.w. of M. charantia seed extracts for 4 weeks thereafter 5 ml/kg of Noni for another 4 weeks. Group IV (MC50 (8wk)+N5 (8wk)): received 50 mg/100 g b.w. of M. charantia seed extracts and 5 ml/kg of Noni concurrently for 8 weeks. Group V (N5 (8wk)): received 5 ml/kg of Noni alone for 8 weeks. Group VI (N5 (4wk)-MC50 (4wk)): treated with 5 ml/kg of Noni for 4 weeks and 50 mg/100 g b.w. of M. charantiaseed extracts for another 4 weeks. The animals were sacrificed on day 57. The testes harvested cleared off surrounding connective tissues and processed for histology.Comparing the slides from treated rats to control, histology showed depletion of spermatogenic cells lines in the seminiferous tubular lumen in MC50 (8wk). This indicates a harmful effect of the extract. Those exposed to Noni, concurrently or otherwise (N5(8wk),MC50(4wk)-N5 (4wk) and MC50 (8wk) +N5 (8wk)) tended towards the normal reference. Light microscopic evidence supports the ameliorative effect of Tahitian Noni dietary supplement on the testicular toxicity induced by high dose M. charantia extract.

 

Key words: Momordica charantia, Tahitian Noni sprague-dawley, histology, testes.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 4 No. 2
Back to articles
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES