International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 128

Full Length Research Paper

Comparision between the effects of dietary suplements of sun dried or sulfur fumigated apricots on the telomerase activity and oxidatıve stress parameters in azoxymethane administered rats

Aysun Bay Karabulut*
  • Aysun Bay Karabulut*
  • Department of Biochemistry, Faculty of Medicine, ?nönu University, Malatya, Turkey.
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Dinçer Özgör
  • Dinçer Özgör
  • Department of General Surgery, ?nönu University, Malatya, Turkey.
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Simay Gürocak
  • Simay Gürocak
  • Department of Radiation Oncology, Faculty of Medicine, ?nonu University, Malatya, Turkey.
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Nese Karadag
  • Nese Karadag
  • Department of Pathology, Faculty of Medicine, ?nonu University, Malatya, Turkey.
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Onder Otlu
  • Onder Otlu
  • Department of Biochemistry, Faculty of Medicine, ?nonu University, Malatya, Turkey.
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Cemil Colak
  • Cemil Colak
  • Department of Bioistatistics, Faculty of Medicine, ?nonu University, Malatya, Turkey.
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  •  Received: 22 April 2014
  •  Accepted: 31 October 2014
  •  Published: 30 November 2014

Abstract

This study was conducted to evaluate the protective effects of organic and sulfur treated apricot on the azoxymethane-induced carcinogenesis by antioxidant markers and telomerase activity. Spraque Dawley rats (n = 35) were fed with  two kinds of  dried apricots (sun-dried or sulfur fumigated), with or without azoxhymethane (AOM). Rats were sacrificed after seven weeks for measurement of reduced  glutathione,  malondialdehyde, nitric oxide levels and  telomerase activity. The results demonstrated that, oxidative stress and telomerase activity were increased in AOM induced group; decreased in apricot fed group (p < 0.001). With respect to the antioxidant activity; sulfur fumigated apricot group could be more effective than the sun-dried apricot (p < 0.005). On the contrary, telomerase activity was found to be higher in AOM induced sulfur fumigated apricot  group compared to that of the group with AOM  and organic apricot. These results demonstrate that sulfur fumigated apricot or sun dried apricot + azoxhymethane groups had higher antioxidant activity compared to azoxhymethane group. Sun-dried apricot decreaseD the telomerase activity more than sulphur fumigated apricot in azoxyhmethane administirated rats. Apricot treatment also decreased oxidative damage. Taken together, reduction in both telomerase activity and oxidative stress might indicate the benefical effects of apricot suplements against the damages caused by azoxhymethane in rats.

 

Key words: Apricot, azoxhymethane, glutathione, malondialdehyde, nitric oxide, telomerase.  

Abbreviation

AOM, Azoxhymethane; GSH, glutathione; MDA, malondialdehyde; NO, nitric oxide; ip, intraperitoneal; s.c, subcutaneous; AOM+SDA, azoxhymethane+sun dried apricot; AOM+SFA, azoxhymethane+sulfur fumigated apricots; SDA, sun dried apricot; SFA, sulfur fumigated apricot; TRAP, telomeric repeat amplification protocol; SPSS, statistical package for social sciences; ROS, reactive oxygen species; SO2, sulphur dioxide; GSSG, glutathione disulfide; ACF, aberrant crypt foci.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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