Abstract

Approximately 0.7 to 2% of the general population have thrombophilia, but it is estimated that intrauterine growth restriction (IUGR) is due to thrombophilia in 35% of cases. Although the role of thrombophilia in IUGR is not completely known but its destructive effect on placental vasculature is the pathophysiologic cause of defect in transfer of oxygen for fetal growth. The aim of the present study was to determine the role of thrombophilia in fetal growth. This was a case-control study with prospective enrollment. In this study, sera from 43 pregnant women with IUGR and 20 pregnant women with appropriate fetal growth as control were tested for thrombophilia polymorphism (protein S, protein C, factor V leiden, antithrombin III, homocystein, lupus anticoagulant Ab, Anti caradiolipin Ab). Data collection forms and SPSS software were used for analyses. Of 43 women with IUGR, 13(30.2%) and 1(5%) in the control group had positive results for thrombophilia (P=0. 027, OR=8.23). By using logistic regression test, there was significant relation between thrombophilia polymorphism and growth of femur length. We found correlation between the presence of thrombophilia factor and femur length, but in previous studies thrombophilia was correlated with fetal growth restriction and specific fetal biometry does not mention whether fetal index is under the influence of thrombophilia.

Key words: Thrombophilia, pregnancy, intrauterine growth restriction