International Journal of
Nursing and Midwifery

  • Abbreviation: Int. J. Nurs. Midwifery
  • Language: English
  • ISSN: 2141-2456
  • DOI: 10.5897/IJNM
  • Start Year: 2009
  • Published Articles: 212

Full Length Research Paper

The relationship between thrombophilia and intrauterine growth restriction

Fakhrolmolouk Yassaee
  • Fakhrolmolouk Yassaee
  • Infertility and Reproductive Health Research Center, Shaheed Beheshti Medical Sciences University, Evin, 3rd Floor, Taleghani Hospital, Tehran, Iran.
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Parisa Taherzadeh
  • Parisa Taherzadeh
  • Infertility and Reproductive Health Research Center, Shaheed Beheshti Medical Sciences University, Evin, 3rd Floor, Taleghani Hospital, Tehran, Iran.
  • Google Scholar
Ali Reza Abadi
  • Ali Reza Abadi
  • Infertility and Reproductive Health Research Center, Shaheed Beheshti Medical Sciences University, Evin, 3rd Floor, Taleghani Hospital, Tehran, Iran.
  • Google Scholar


  •  Accepted: 20 July 2011
  •  Published: 30 October 2011

Abstract

 

Approximately 0.7 to 2% of the general population have thrombophilia, but it is estimated that intrauterine growth restriction (IUGR) is due to thrombophilia in 35% of cases. Although the role of thrombophilia in IUGR is not completely known but its destructive effect on placental vasculature is the pathophysiologic cause of defect in transfer of oxygen for fetal growth. The aim of the present study was to determine the role of thrombophilia in fetal growth. This was a case-control study with prospective enrollment. In this study, sera from 43 pregnant women with IUGR and 20 pregnant women with appropriate fetal growth as control were tested for thrombophilia polymorphism (protein S, protein C, factor V leiden, antithrombin III, homocystein, lupus anticoagulant Ab, Anti caradiolipin Ab). Data collection forms and SPSS software were used for analyses. Of 43 women with IUGR, 13(30.2%) and 1(5%) in the control group had positive results for thrombophilia (P=0. 027, OR=8.23). By using logistic regression test, there was significant relation between thrombophilia polymorphism and growth of femur length. We found correlation between the presence of thrombophilia factor and femur length, but in previous studies thrombophilia was correlated with fetal growth restriction and specific fetal biometry does not mention whether fetal index is under the influence of thrombophilia.

 

Key words: Thrombophilia, pregnancy, intrauterine growth restriction