Background: Perinatal mortality refers to "number of stillbirths and deaths in the first week of life per 1000 total births, the perinatal period begins at 22 completed weeks, and ends at the seventh day following child birth". Perinatal mortality is the presumptive indicator remains a challenge to achieve the goal directed at improving maternal and child health status in developing countries. Identifying factors associated is an important step to look for appropriate health interventions for reducing perinatal death. Therefore, the aim of this study was to assess the prevalence of perinatal mortality and its associated factors among mothers who gave birth at Arba Minch General Hospital, Southern Ethiopia. Methods: A health based cross-sectional study design using secondary data as source information was conducted among 422 randomly selected study participants in Arba Minch General Hospital from September/2016 to August/2017. Secondary data as source of information was used to extract data from study subjects. Epi-info version 7.0 and SPSS Version 21 were used for data entry and analysis respectively. Descriptive statistics, frequencies, proportions, and diagrams were used to describe the study population. Bi-variable and multivariable analyses were computed to identify important variables associated with perinatal mortality. Results: - The magnitude of perinatal mortality was 7.4% (95%CI). In multiple logistic analysis, no previous antenatal care visit [(AOR=7.48, 95% CI: (2.04, 27.50)], preterm deliveries[(AOR=11.8, 95%CI: (3.09, 44.99)], prolonged labor[(AOR=11.12, 95%CI:(2.32, 53.31)], premature rupture of membrane[(AOR=9.32, 95%CI: (2.08, 41.78)], preeclampsia[(AOR=13.43, 95%CI: (2.54, 70.78)] antepartum hemorrhage [(AOR=42.51, 95%CI: (7.66, 235.94)] and cord prolapse[(AOR=19.06, 95%CI: (2.07, 175.01)] were main factors associated with perinatal death. Conclusions: Perinatal mortality in Arba Minch General Hospital is low. The main contributing factors identified for perinatal death are preventable with application of using the existing maternal health programs. A collaborative effort is needed in amplifying the existing maternal and newborn health services to lower risk of perinatal death.