Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3835

Full Length Research Paper

In vitro evaluation of antimicrobial activity of combinations of nystatin and Euphorbia hirta leaf extract against Candida albicans by the checkerboard method

Clement Jackson1*, Akeem Agboke1 and Victor Nwoke2
1Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria. 2 University Teaching Hospitals, Port Harcourt, Nigeria.
Email: [email protected]

  •  Accepted: 30 June 2009
  •  Published: 30 September 2009

Abstract

The in vitro combined effects of Nystatin and methanol extract of leaves ofEuphorbia hirta against clinical isolates of Candida albicans were investigated using the Checkerboard technique. The organism was susceptible to the extract with MIC of 25 mg/ml, while Nystatin had MIC of 0.165 mg/ml against C. albicans. Upon combination, some ratios showed synergistic while others indicated indifferent activities against the isolates. These results indicate that some combinations of the extract with nystatin could be synergistic in activity for some ratio combinations and indifferent for some others.

 

Key words: In vitro, nystatin, Euphorbia hirta, Candida albicans, checkerboard.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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