Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

In vitro and in vivo antioxidant activity of Ixora coccinea

Surana A. R.1*, Aher A. N.2 and Pal S. C.2
1S.M.B.T. College of Pharmacy, Dhamangaon, Tal-Igatpuri, Dist-Nashik, M.S.422403, India. 2N.D.M.V.P. Samaj’s College of Pharmacy, Nashik, M.S-422003, India.
Email: [email protected]

  •  Accepted: 10 October 2013
  •  Published: 03 November 2013

Abstract

Ixora coccinea Linn. commonly known as Rangon, belongs to the family Rubiaceae. Antioxidant activity of root of I. coccinea extract was evaluated in a series of in vitro assay involving free radicals. IC50 values were determined. Extracts of I. coccinea exhibited scavenging effect in concentration dependent manner in all in vitro method. IC50 of ethyl acetate extract was 48.43, 75.811 and 60.60 µg/ml for 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging, hydrogen peroxide scavenging, nitric oxide scavenging, respectively. Ethyl acetate extract shows good in vitro antioxidant activity compared to other extract. The extract was also studied for in vivo antioxidant activity by prolongation of haloperidol induced catalepsy. Methanolic extract shows good in vivo antioxidant activity compared to other extract.

Key words: Ixora coccinea, DPPH free radical, nitric oxide radical, hydrogen peroxide scavenging, haloperidol induced catalepsy.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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