Abstract

Ethyl acetate extract of wheat (Triticum aestivum) and methanolic extract of garlic (Allium sativum) were obtained by fermenting powdered wheat germ and garlic bulbs. The extracts were assessed for their active constituents. The result of the quantitative phytochemical analysis shows that the plant contain secondary metabolite with high percentage of glycoside (19.513%), alkaloids (4.017%) and saponins(7.992%) for wheat extract and glycoside (21.088%), alkaloids(3.570%) and saponins (0.696%) for garlic extract. The extract exhibit antit-rypanosomal activity by showing decrease in the proliferation of parasite and extension of surviving days of Trypanosoma brucei - infected rats from 8 days of the control (infected-untreated) to 14 days of infected treated with wheat and 17 days for infected treated with garlic extract. This study scientifically demonstrates the potential of fermented wheat germ ethylacetate extract and garlic bulbs methanolic extract in the management of Africa trypanosomiasis.

Key words: Anti–trypanosomal, wheat germ, garlic bulbs, Africa trypanosomiasis, phytochemicals