Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3834

Full Length Research Paper

Modulatory antibiotic activity and chemical composition of hydroalcoholic extract of Croton campestris

Francisco E. B. Junior1, Edinardo F. F. Matias2, Dayanne R. Oliveira1, Andreza G. B. Ramos1, Cícera N. Fernandes1, Heloisa H. F. Souza1, Luiz J. Lacerda Neto1, Anita O. B. Pereira1, Mariana K. A. Araruna1, Francisco A. V. Santos4, Henrique D. M. Coutinho2*, Jose G. M. Costa3, Marta R. Kerntopf 1 and Irwin R. A. Menezes1
1Laboratory of Medicinal Chemistry and Pharmacology (LFQM), Department of Biological Chemistry, Regional University of Cariri, Cel. Antonio Luis 1161, Crato-CE, Brazil. 2Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry, Regional University of Cariri, Cel. Antonio Luis 1161, Crato-CE, Brazil. 3Laboratory of Natural Products Research (LPPN), Department of Biological Chemistry, Regional University of Cariri, Cel. Antonio Luis 1161, Crato-CE, Brazil. 4Leão Sampaio College, Leao Sampaio Avenue, Juazeiro do Norte-CE, Brazil.
Email: [email protected]

  •  Accepted: 17 August 2011
  •  Published: 16 September 2011

Abstract

Croton campestris A. St.-Hill., known as "Velame do campo" (Euphorbiaceae), native of the Brazilian Northeastern region, is used in the popular medicine as decoction against several diseases as inflammations, hematological disturbances, flu and gastritis. The study analyzed the chemical composition and the antibacterial activity against bacterial strains ofEscherichia coli and Staphylococcus aureus of the hydroalcoholic extract of the leaves of the C. campestris (HEFCC). The inhibition of the bacterial growth was demonstrated for the bacteria tested with MIC values ≥ 1024 µg/ml. When combined with aminoglycosides (gentamicin, kanamycin, amikacin and neomycin), the extract demonstrated synergistic effect. This result showed that HEFCC can be used as promisor font of new antimicrobial compounds for pathogenic diseases.

 

Key words: Croton campestris, antimicrobial activity, modulatory aminoglycoside effect, antimicrobial activity, antibiotic, synergism.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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