Traditional medicine is used in all over the world, especially in developing countries. Though synthetic drugs are very effective but are harmful to human beings because of their side effects. Genus of Terminalia and Combretum species are belong to the family Combretaceae, which contains 20 genera and 600 species as herbs, shrubs and trees. These plants are used in different traditional medicine for their antioxidant property and also for the treatment of hepatitis and malaria due to presence of antibacterial properties. The present study is focused onchemo- profiling,screening of the antioxidant compound, antioxidant activities and antimicrobial properties of different Terminalia and Combretum species, namely Terminalia arjuna, T.alata, T. bellerica, T. cataappa, T. chebulla, T. bucera and T. mauritiana,, Combretum albidum, C. roxburghii and C.indicum. Four different concentrations (20, 40, 60 and 80 mg/ml) of methanolic extracts of leave and bark of these plant species were tested against six bacterial pathogens i.e Streptococcus epidermis, Salmonella enterica, Staphylococcus aureus, Escherichia coli, Bacillus subtillis and Pseudomonas aeruginosa using disc diffusion method. It was observed that the methanolic leaf and bark extract T.arjuna, T.chebulla and C. albidum proved remarkable anti-bacterial properties against the different bacterial strains. This study will help to know the properties of medicinal plants for making different formulation of different types of green medicine.

Keywords: Chemo- profiling,HPTLC, antibacterial assay, DPPH assay, Combretaceae plants.