This study explores the therapeutic potential of Copaifera langsdorffii Desf. (Fabaceae), commonly known as Copaíba, a legume renowned for its oleoresin extraction. The organic extracts from Copaíba's leaves, stem bark, and wood, using n-hexane, ethyl acetate, and methanol, were investigated for their antimicrobial, antioxidant, and anti-inflammatory activities. In vitro assessments included determining minimum inhibitory concentration (MIC) against P. aeruginosa, S. aureus, and C. albicans, DPPH• radical scavenging and quantifying inflammatory mediators (NO, TNF-?, IL-6, IL-10) produced by LPS-stimulated murine peritoneal macrophages (MPM). Phytochemical analysis using thin-layer chromatography (TLC) unveiled various secondary metabolites in the extracts, with particularly active ones exhibiting high levels of flavonoids, terpenes, and coumarins. The findings emphasize the importance of conserving Copaíba species and leveraging its traditional medicinal use across diverse ailments. Notably, this research paves the way for exploring alternative plant parts without compromising the integrity of oleoresin extraction. The identified bioactive compounds in Copaíba suggest a promising correlation with its observed therapeutic effects, highlighting its potential as a valuable natural resource in the treatment of various diseases.

Keywords: Phytochemical screening, biological activities, Copaifera langsdorffii, extracts.