Journal of
Public Health and Epidemiology

  • Abbreviation: J. Public Health Epidemiol.
  • Language: English
  • ISSN: 2141-2316
  • DOI: 10.5897/JPHE
  • Start Year: 2009
  • Published Articles: 655

Full Length Research Paper

Incidence of glucose-6-phosphate dehydrogenase deficiency in anaemic patients attending General Hospital Kafanchan, Kaduna State, Nigeria

Abubakar, A.*
  • Abubakar, A.*
  • Zonal Headquater N.W., Nigerian Institute for Trypanosomiasis Research, PMB 1147, Birnin Kebbi, Kebbi State, Nigeria.
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Opata, M. O
  • Opata, M. O
  • Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom, Plateau State, Nigeria.
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Zubair A. I.
  • Zubair A. I.
  • Zonal Headquater N.W., Nigerian Institute for Trypanosomiasis Research, PMB 1147, Birnin Kebbi, Kebbi State, Nigeria.
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Maigari, A. K
  • Maigari, A. K
  • Zonal Headquater N.W., Nigerian Institute for Trypanosomiasis Research, PMB 1147, Birnin Kebbi, Kebbi State, Nigeria.
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Yusuf, A. B
  • Yusuf, A. B
  • Zonal Headquater N.W., Nigerian Institute for Trypanosomiasis Research, PMB 1147, Birnin Kebbi, Kebbi State, Nigeria.
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Okwonkwo, P. O
  • Okwonkwo, P. O
  • Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom, Plateau State, Nigeria.
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Duru, B. N
  • Duru, B. N
  • Chemical Pathology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom, Plateau State, Nigeria.
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Junaid, S. A
  • Junaid, S. A
  • Microbiology Department, Federal College of Veterinary and Medical Laboratory Technology, National Veterinary Research Institute (NVRI), Vom, Plateau State, Nigeria.
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Mokogwu A. T. H
  • Mokogwu A. T. H
  • Department of Chemical Pathology, School of Clinical Medicine, Igbinedion University, Okada, Nigeria
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  •  Received: 05 January 2015
  •  Accepted: 28 January 2015
  •  Published: 28 February 2015

Abstract

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is one of the most well known human genetic defects and could possibly result in acute haemolysis after exposure to various oxidative conditions. This work was therefore carried out to determine the incidence of G-6-PD deficiency in anaemic patients attending General Hospital Kafanchan, Kaduna State, Nigeria. The study group comprised of 50 sickle cell, 60 iron deficient and 40 malaria patients, while 50 apparently healthy individuals served as control. Statistical analyses of the results according to age group, sex, marital status, packed cell volume (PCV) values, G-6-PD activities and genotype revealed 24 (12%), 26 (13%) and 6 (3%) were G-6-PD deficient in sickle cell, iron deficiency anaemia and apparently healthy, respectively. G-6-PD deficiency was absent in all malaria patients screened. In terms of marital status, singles of both males and females recorded higher deficiency than their married counterpart (P < 0.05). Furthermore, the age interval of 0 to 10 years old recorded highest number of G-6-PD deficient subjects in all the anaemic patients (P < 0.05). The study therefore suggests the need for routine G-6-PD screening test on anaemic patients to avoid factors which could further precipitate haemolytic crisis.

 

Key words: Incidence, glucose-6-phosphate dehydrogenase (G-6-PD), anaemia, haemolysis, Kafanchan, Nigeria.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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