Journal of
Public Health and Epidemiology

  • Abbreviation: J. Public Health Epidemiol.
  • Language: English
  • ISSN: 2141-2316
  • DOI: 10.5897/JPHE
  • Start Year: 2009
  • Published Articles: 655

Full Length Research Paper

A qualitative study on experiences of HIV vaccine trial participants in a phase I/II double-blinded, randomized placebo-controlled clinical trial in Tanzania: Lessons for COVID-19 vaccine testing

Erica S. Sanga
  • Erica S. Sanga
  • 1NIMR-Mwanza Medical Research Centre, Mwanza, Tanzania. 2NIMR-Mbeya Medical Research Centre (MMRC), Mbeya, Tanzania. 3The School of Public Health, University of Western Cape, South Africa.
  • Google Scholar
Brian Van Wyk
  • Brian Van Wyk
  • The School of Public Health, University of Western Cape, South Africa.
  • Google Scholar
Leonard L. Maboko
  • Leonard L. Maboko
  • 2NIMR-Mbeya Medical Research Centre (MMRC), Mbeya, Tanzania., 4Tanzania Commission for AIDS (TACAIDS), Dar-es-Salaam-Tanzania.
  • Google Scholar
Simukai Shamu
  • Simukai Shamu
  • The School of Public Health, University of Western Cape, South Africa., 5Foundation for Professional Development, Health Systems Strengthening Division, Pretoria, South Africa. 6The University of the Witwatersrand, School of Public Health, Johannesburg, South Africa.
  • Google Scholar


  •  Received: 14 June 2021
  •  Accepted: 27 July 2021
  •  Published: 31 August 2021

References

Arroyo MA, Hoelscher M, Sateren W, Maboko L, Hoffmann O, Kijak G, Robb M, Birx DL, Mccutchan FE (2005). HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania. February, pp. 1517-1524.
Crossref

 

BBC (2020). Coronavirus: Africa will not be testing ground for vaccine. Says WHO. BBC.com.

 
 

Braun V, Clarke V (2006). Using thematic analysis in psychology. Qualitative Research in Psychology 3(May 2015) :77-101. https://doi.org/10.1191/1478088706qp063oa
Crossref

 
 

Chenneville T, Gabbidon K, Hanson P, Holyfield C (2020). The impact of COVID-19 on HIV treatment and research: A call to action. In International Journal of Environmental Research and Public Health. 
Crossref

 
 

Chin LJ, Berenson JA, Klitzman RL (2016). Typologies of altruistic and financial motivations for research participation: A qualitative study of MSM in HIV vaccine trials. Journal of Empirical Research on Human Research Ethics 11(4) :299-310. 
Crossref

 
 

Communications and Global Advocacy UNAIDS (2020). UNAIDS FACT SHEET. Global HIV Statistics. Ending the AIDS Epidemic, pp. 1-3.

 
 

Coutinho BA, Dtm MMPH (2020). Covid-19 in Africa: Scenarios and Signposts COVID-19 in Numbers Africa Has Growing Clinical Trial Experience Which. 10119.

 
 

Detoc M, Bruel S, Frappe P, Botelho-Nevers E, Gagneux-Brunon A (2020). Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. Vaccine, 38(45):7002-7006. 2020.04.23.20076513. 
Crossref

 
 

Doshi M, Avery L, Kaddu RP, Gichuhi M, Gakii G, Du Plessis E, Dutta S, Khan S, Kimani J, Lorway RR (2017). Contextualizing willingness to participate: recommendations for engagement, recruitment & enrolment of Kenyan MSM in future HIV prevention trials. BMC Public Health 17(1) :1-12. 
Crossref

 
 

Fereday J (2006). Demonstrating Rigor Using Thematic Analysis?: A Hybrid Approach of Inductive and Deductive Coding and Theme Development. International Journal Of Qualitative Methods 5(1) :80-92. 80-92.
Crossref

 
 

Getz KA, Campo RA (2017). Trial watch: Trends in clinical trial design complexity. Nature Reviews Drug Discovery 16(5):307-308.
Crossref

 
 

Greenhalgh T, Taylor R (1997). How to read a paper: Papers that go beyond numbers (qualitative research). BMJ Clinical Research, 26(2):54-60. 
Crossref

 
 

Hargreaves J, Davey C, Auerbach J, Blanchard J, Bond V, Bonell C, Burgess R, Busza J, Colbourn T, Cowan F, Doyle A, Hakim J, Hensen B, Hosseinipour M, Lin L, Johnson S, Masuka N, Mavhu W, Mugurungi O, Yekeye R (2020). Three lessons for the COVID-19 response from pandemic HIV. The Lancet HIV 7(5):e309-e311.
Crossref

 
 

Kamazima SR, Kakoko DCV, Kazaura M (2020). Manifold Tactics are used to Control and Prevent Pandemics in Contemporary Africa": A Case of Tanzania's Fight against COVID-19. International Journal of Advanced Scientific Research and Management 5(11):20. 
Crossref

 
 

Koff WC (2012). HIV vaccine development: Challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem. Vaccine 30(29):4310-4315. 
Crossref

 
 

Lin D, Sun S, Operario D, Normal B (2020).Willingness to Participate in a COVID-19 Vaccine Trial Among Young Adults in China. Available at SSRN 3615937.

 
 

Lurie N, Saville M, Hatchett R, Halton J (2020).Developing Covid-19 vaccines at pandemic speed. New England Journal of Medicine 382(21):1969-1973.
Crossref

 
 

Mbunda T, Bakari M, Tarimo EA, Sandstrom E, Kulane A (2014). Factors that influence the willingness of young adults in Dar es Salaam, Tanzania, to participate in phase I/II HIV vaccine trials. Global Health Action 7(1):22853. 
Crossref

 
 

Mfinanga SG, Mnyambwa NP, Minja DT, Ntinginya NE, Ngadaya E, Makani J, Makubi AN (2021). Correspondence Tanzania ' s position on the COVID-19 pandemic. The Lancet 6736(21):6736. 
Crossref

 
 

Mills E, Cooper C, Guyatt G, Gilchrist A, Rachlis B, Sulway C, Wilson K (2004).Barriers to participating in an HIV vaccine trial: a systematic review. Aids 18(17):2235-2242. 
Crossref

 
 

Newman PA, Duan N, Roberts KJ, Seiden D, Rudy ET, Swendeman D, Popova S (2006).HIV vaccine trial participation among ethnic minority communities: Barriers, motivators, and implications for recruitment. Journal of Acquired Immune Deficiency Syndromes 
Crossref0

 
 

Nyaoke BA, Mutua GN, Sajabi R, Nyasani D, Mureithi MW, Anzala OA (2017). Volunteer motivators for participating in HIV vaccine clinical trials in Nairobi, Kenya. PLoS One. 
Crossref

 
 

Opeyemi US, Kayode AF, Nafisat UI (2017). O16.6 Willingness of young persons in south-western nigeria to participate in early hiv vaccine trials. 
Crossref

 
 

Pronker ES, Weenen TC, Commandeur H, Claassen EHJHM, Osterhaus ADME (2013). Risk in Vaccine Research and Development Quantified. PLoS One. 
Crossref

 
 

Tarimo EAM, Bakari M, Kakoko DCV, Kohi TW, Mhalu F, Sandstrom E, Kulane A (2016). Motivations to participate in a Phase I/II HIV vaccine trial: A descriptive study from Dar es Salaam, Tanzania. BMC Public Health. 
Crossref

 
 

Tarimo EAM, Ambikile J, Munseri P, Bakari M (2019). Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania. PLoS One. 1
Crossref

 
 

Thabethe S, Slack C, Lindegger G, Wilkinson A, Wassenaar D, Kerr P, Bekker LG, Mngadi K, Newman PA (2018). "Why Don't You Go Into Suburbs? Why Are You Targeting Us?": Trust and Mistrust in HIV Vaccine Trials in South Africa. Journal of Empirical Research on Human Research Ethics. 
Crossref

 
 

Thanh Le T, Andreadakis Z, Kumar A, Gómez RR, Tollefsen S, Saville M, Mayhew S (2020). The COVID-19 vaccine development landscape. In Nature reviews. Drug Discovery 19(5):305-306. 
Crossref

 
 

THIS (2017). December 2017 Tanzania Hiv Impact Survey (THIS). December 2017 :2016-2017.

 
 

Tong A, Sainsbury P, Craig J (2007). Consolidated criterio for reporting qualitative research (COREQ): a 32- item checklist for interviews and focus group. International Journal of Qualitative in Health Care 19(6):349-357.
Crossref

 
 

UNAIDS (2019). Global plan Country fact sheet-Tanzania.

View

 
 

UNAIDS. (2020). AIDS Fact sheet: Global HIV statistics.

 
 

World Health Organization (WHO) (2020). Coronavirus Disease 2019. In WHO (Vol. 14, Issue 6). 
Crossref