Journal of
Toxicology and Environmental Health Sciences

  • Abbreviation: J. Toxicol. Environ. Health Sci.
  • Language: English
  • ISSN: 2006-9820
  • DOI: 10.5897/JTEHS
  • Start Year: 2009
  • Published Articles: 217

Full Length Research Paper

Benzene, toluene, ethylene and xylene (BTEX) is implicated in gasoline-induced oxidative stress in male albino Wistar rats

Friday E. Uboh
  • Friday E. Uboh
  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Nigeria.
  • Google Scholar
Saviour U. Ufot
  • Saviour U. Ufot
  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Nigeria.
  • Google Scholar
Uduak O. Luke
  • Uduak O. Luke
  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Nigeria.
  • Google Scholar
Eve Mboso
  • Eve Mboso
  • Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Nigeria.
  • Google Scholar


  •  Received: 19 March 2019
  •  Accepted: 11 June 2019
  •  Published: 31 December 2022

References

Abubakar MB, Abdullah WZ, Sulaiman SA, Uboh FE, Ang BS (2013). Effect of honey supplementation on toxicity of gasoline vapor exposure in rats. International Journal of Applied Research in Natural Products 6(4):16-22.

 

Aseervatham GSB, Sivasudha T, Jeyadevi R, Ananth DA (2013). Environmental factors and unhealthy lifestyle influence oxidative stress in humans-an overview. Environmental Science and Pollution Research 20(7):4356-4369.
Crossref

 
 

Agency for Toxic Substances and Disease Registry (ATSDR) (2007). Toxicological Profile For Benzene. U.S. Department Of Health And Human Services. Agency for Toxic Substances and Disease Registry, Atlanta, GA, 2007.

 
 

Barath S, Mills NL, Lundbäck M, Törnqvist H, Lucking AJ, Langrish JP, Donaldson K (2010). Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Particle and Fibre Toxicology 7(1):19.
Crossref

 
 

Caselli M, de Gennaro G, Marzocca A, Trizio L, Tutino M (2010). Assessment of the impact of the vehicular traffic on BTEX concentration in ring roads in urban areas of Bari (Italy). Chemosphere 81(3):306-311.
Crossref

 
 

Correa SM, Arbilla G, Marques MR, Oliveira KM (2012). The impact of BTEX emissions from gas stations into the atmosphere. Atmospheric Pollution Research 3(2):163-169.
Crossref

 
 

Dede EB, Kagbo HD (2001).Investigation of acute toxicological effects of diesels fuel in rats (Rattus rattus) using Histopathological methods. Journal of Applied Sciences and Environmental Management 5(1): 83-84.
Crossref

 
 

Egeghy PP, Tornero-Velez R, Rappaport SM (2000). Environmentaland biological monitoring of benzene during self-service automobile refueling. Environmental Health Perspectives 108(12):1195-1202.
Crossref

 
 

Eriyamremu GE, Osagie VE, Omoregie SE, Omofoma CO (2008). Alterations in glutathione reductase, superoxide dismutase, and lipid peroxidation of tadpoles (Xenopus laevis) exposed to Bonny Light crude oil and its fractions. Ecotoxicology and Environmental Safety 71(1):284-290.
Crossref

 
 

Gbadebo AM, Taiwo AM, Ola OB (2009). Effects of crude oil and spent oil on Clarias garipinus: a typical marine fish. American Journal of Environmental Sciences 5(6):753-758.
Crossref

 
 

Keprasertsup C, Bashkin V, Wangwongwatana S, Pokethitiyook P, Adsavakulchai S, Towprayoon S (2003). Concentrations of MTBE, Benzene, Toluene, Ethylbenzene, and Xylene in Ambient Air at Gas Stations and Traffic Area in Bangkok. Proceedings of the 2nd Regional Conference on Energy Technology Towards a Clean Environment, Phuket, Thailand; 12-14: p 5032(O).

 
 

King EJ, Wootton I (1956). Micro-analysis in Medical Biochemistry. J. & A. Churchill

 
 

King MA, Sogbanmu TO, Osibona AO, Doherty VF, Otitoloju AA (2012). Toxicological evaluation and usefulness of lipid peroxidation as biomarker of exposure to crude oil and petroleum products tested against African catfish, Clarias gariepinus and hermit crab, Clibanarius africanus. Nature Environment and Polution Technology 11(1):1-6.

 
 

Li N, Hao M, Phalen RF, Hinds WC, Nel AE (2003). Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clinical Immunology 109(3):250-265.
Crossref

 
 

McHale CM, Zhang L, Smith MT (2012). Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis 33(2):240-252.
Crossref

 
 

National Institute of Health (NIH) (1985). Guide for the care and use of laboratory animals. DHEW Publication. Office of Science and Health Reports, Bethesda, U.S.A.

 
 

National Institute for Occupational Safety and Health (NIOSH) (1990). National Occupational Exposure Survey (1981-83), Cincinnati, OH, 1990.

 
 

Otitoloju A, Olagoke O (2011). Lipid peroxidation and antioxidant defense enzymes in Clarias gariepinus as useful biomarkers for monitoring exposure to polycyclic aromatic hydrocarbons. Environmental Monitoring and Assessment 182(1-4):205-213.
Crossref

 
 

Paglia DE, Valentine WN (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of laboratory and clinical medicine 70(1):158-169.

 
 

Perera FP, Rauh V, Tsai WY, Kinney P, Camann D, Barr D, Dietrich J (2003). Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environmental Health Perspectives 111(2):201-205.
Crossref

 
 

Periago JF, Prado C (2005). Evolution of occupational exposure to environmental levels of aromatic hydrocarbons in service stations. Annals of Occupational Hygiene 49(3):233-240.

 
 

Rekhadevi PV, Rahman MF, Mahboob M, Grover P (2010). Genotoxicity in filling station attendants exposed to petroleum hydrocarbons. Annals of Occupational Hygiene 54(8):944-954.

 
 

Saxena P, Ghosh C (2012). A review of assessment of benzene, toluene, ethylbenzene and xylene (BTEX) concentration in urban atmosphere of Delhi. International Journal of the Physical Sciences 7(6):850-860.
Crossref

 
 

Sengupta P, Banerjee R (2014). Environmental toxins: Alarming impacts of pesticides on male fertility. Human and Experimental Toxicology 33(10):1017-1039.
Crossref

 
 

Tang D, Li TY, Liu JJ, Chen YH, Qu L, Perera F (2006). PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohort. Environmental Health Perspectives 114(8):1297-1300.
Crossref

 
 

Thaveevongs P, Panyamateekul S, Prueksasit T (2010). Exposure risk assessment of volatile organic compounds (VOCs) of the workers at gas station in Bangkok. Engineering Journal 2(3):1-12.

 
 

Tunsaringkarn T, Choochat N, Theppitaksak B (2004). Headspace -Solid Phase Microextraction for determination of benzene, toluene, ethylbenzene, xylene and MTBE in blood. Journal of Health Research 18(1):4959

 
 

Tunsaringkarn T, Soogarun S, Rungsiyothin A, Zapuang K, Chapman RS (2011). Health status of gasoline station workers in Pathumwan Area, Bangkok, Thailand, in 2004 and 2009. Journal of Health Research 25(1):15-19.

 
 

Tunsaringkarn T, Zapuang K, Rungsiyothin A (2013). Correlation between blood cell parameters and BTEX exposure among gasoline station workers. Journal of Environmental and Occupational Science 2(1):15-20.
Crossref

 
 

Tunsaringkasrn T, Ketkaew P, Zapaung K, Rugsiyothin A, Taneepanichkul S (2011). Risk Ratio of Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) Exposures and Their Relations to Biological Parameters of Gasoline Workers in Bangkok, Thailand. Applied Environmental Research 33(1):27-38.

 
 

Uboh FE, Akpanabiatu MI, Alozie Y (2008). Comparative effect of gasoline vapours on renal functions in male and female albino wistar rats. Journal of Pharmacology and Toxicology 3(6):478-484.
Crossref

 
 

Uboh FE, Akpanabiatu MI, Atangwho IJ, Alozie Y (2008). Exposure to gasoline vapours: a potential risk factor for atherosclerosis in male and female rats. Journal of Pharmacology and Toxicology 3(8):600-609.
Crossref

 
 

Uboh FE, Akpanabiatu MI, Atangwho IJ, Ebong PE, Umoh IB (2007). Effect of gasoline vapours on serum lipid profile and oxidative Stress in hepatocytes of male and female rats. Acta Toxicologica 15(1):25-30

 
 

Uboh FE, Akpanabiatu MI, Ebong PE and Umoh IB (2007). Gender differences in the Haematotoxicity and weight changes associated with exposure to gasoline vapours in wistar albino rats. Acta Toxicologica 15(2):125-131

 
 

Uboh FE, Akpanabiatu MI, Ebong PE, Eyong EU and Ekaidem IS (2005b). Evaluation of to toxicological implications of inhalation exposure to kerosene and petrol fumes in rats. Acta Biol. Szegiend 49(3-4):19-22.
Crossref

 
 

Uboh FE, Akpanabiatu MI, Edet EE, Ebong PE (2010). Increase activity of serum total and prostatic acid phosphatase, alkaline phosphatase, gamma glutamyltransferase and testosterone level in rats exposed to gasoline vapours. Journal of Medicine and Medical Sciences 1(1):016-020.

 
 

Uboh FE, Akpanabiatu MI, Ekaidem IS, Ebong PE, Umoh IB (2007a). Effect of Inhalation Exposure to Gasoline Vapours On Sex Hormones Profile In Wistar Albino Rats. Acta Endocrinologica (Buc) 3(1):23-30
Crossref

 
 

Uboh FE, Akpanabiatu MI, Ndem JI, Alozie Y, Ebong PE (2009). Comparative nephrotoxic effect associated with exposure to diesel and gasoline vapours in rats. Journal of Toxicology and Environmental Health Sciences 1(4):68-74.

 
 

Uboh FE, Ebong PE, Eka OU, Eyong EU, Akpanabiatu, MI (2005). Effect of inhalation exposure to kerosene and petrol-fumes on some anaemia-diagnostic indices in rats. Global Journal of Environmental Sciences 4(1):59-63.
Crossref

 
 

Uboh FE, Ufot SU, Eyong EU (2013). Comparative effect of withdrawal from exposure on gasoline and diesel induced nephrotoxicity in male albino wistar rats. Journal of Clinical Toxicology 3(170):2161-0495.

 
 

Van de Wiel JAG, Fijneman PHS, Duijf CMP, Anzion RBM, Theuws JLG, Bos RP (1993). Excretion of benzo [a] pyrene and metabolites in urine and feces of rats: influence of route of administration, sex and long-term ethanol treatment. Toxicology 80(2-3):103-115.
Crossref

 
 

Van Schooten FJ, Moonen EJC, Van der Wal L, Levels P, Kleinjans JCS (1997). Determination of polycyclic aromatic hydrocarbons (PAH) and their metabolites in blood, feces, and urine of rats orally exposed to PAH contaminated soils. Archives of Environmental Contamination and Toxicology 33(3):317-322.
Crossref

 
 

Verma DK,Tombe KD (2002). Benzene in gasoline and crude oil: occupational and environmental implications. AIHA Journal 63(2):225-230.
Crossref

 
 

Wallin B, Rosengren B, Shertzer HG, Camejo G (1993). Lipoproteinoxidation and measurement of TBARS formation in a single microlitre peate; its use for evaluation of antioxidants. Analytical Biochemistry 208(1):10-15.
Crossref

 
 

Weisel CP (2010). Benzene exposure: an overview of monitoring methods and their findings. Chemico-Biological Interactions 184(1-2):58-66.
Crossref

 
 

Xin Z, Waterman DF, Hemken RW, Harmon RJ (1991). Effects of copper status on neutrophil function, superoxide dismutase, and copper distribution in steers. Journal of Dairy Science 74(9):3078-3085.
Crossref

 
 

Yimrungruang D, Cheevaporn V, Boonphakdee T, Watchalayann P, Helander HF (2008). Characterization and health risk assessment of volatile organic compounds in gas service station workers. Environment Asia 2:21-29.