Abstract

The aim of this study was to evaluate the tissue biocompatibility of Resilon compared to gutta-percha cones. Three subcutaneous pockets were made in the back of 36 rats weighing between 200 to 250g. Subcutaneous pockets were left unfilled (control, 1 pocket) or filled with Resilon (1 pocket) or gutta-percha (1 pocket). At 3, 10, 30 and 90 days after implantation, 9 rats were killed and the materials were removed with their surrounding tissues. Histological samples were prepared, stained with hematoxylin-eosin (H&E), and observed under light microscopy, and intensity of tissue inflammatory response was assessed. Chi-square and Fisher’s exact tests were used for statistical analysis, with significance defined at the P<0.05 level. No significant differences were seen between the three groups at 3 or 10 days. There were significant differences in tissue reaction between the experimental groups and control group at 30 and 90 days. However, tissue reactions for Resilon and gutta-percha were similar at 30 and 90 days. Within the limits of this study, Resilon had similar tissue compatibility to gutta-percha on rat connective tissue.

Key words: Gutta-percha, Resilon, subcutaneous implantation, tissue-compatibility.