Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2768

Full Length Research Paper

The role of ginger starch as a binder in acetaminophen tablets

Ibezim, E.C1., Ofoefule, S.I2., Omeje, E.O3*, Onyishi V.I2 and Odoh, U. E4.
  1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka, Nigeria. 2Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. 3Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. 4Department of Pharmacognosy, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka, Nigeria.
Email: [email protected]

  •  Accepted: 10 January 2008
  •  Published: 29 February 2008

Abstract

 

The rhizomes of ginger, Zingiber officinale (Roscoe; Zingiberacea) has been reported to contain up to 56.0% starch. The starch was extracted from the fresh rhizomes, evaluated for relevant properties and used as a binder to acetaminophen tablets at concentrations of 2.0 - 8.0% w/w. The tablets were evaluated for hardness, friability, weight uniformity, disintegration and dissolution profiles. Acetaminophen tablets containing gelatin as standard binder were produced and assessed comparatively. Results obtained indicate that ginger starch performed as good as gelatin as a binder to acetaminophen tablets.

 

Key words: Ginger, Zingiber officinale, binder, zingiberacea, acetaminophen.

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