Abstract

The in vitro dissolution profiles of four commercial brands of aspirin tablets (one soluble brand of aspirin, A1, and three plain brands of aspirin labeled A2-A4) were assessed using the USP XXI dissolution method. Various dissolution parameters such as percent dissolution in 30 min, dissolution rate constant (k), and time for 50% dissolution (DT50%) were obtained. The results indicate that A1 (the soluble aspirin brand) exhibited the highest dissolution profile while brand A3 had the least dissolution profile. The relative ranking in terms of percent dissolution in 30 min and dissolution rate constant (K) are in the order of A1>A4>A2>A3, while the ranking of time for 50% dissolution (DT_50%) is in the reverse order of A1<A4<A2<A3. Analysis of variance (ANOVA) performed on the percent dissolved in 30 min showed no significant difference (p > 0.05) among all the brands. They all indicated similar statistical behaviour in terms of their dissolution profiles.

Keywords: Aspirin, dissolution profile, Nigeria.