African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12481

Full Length Research Paper

Suppression of vascular smooth muscle cells’ proliferation and migration by valsartan via MAPK pathway

Songbiao Yan1, Jiefeng Xu2 and Hui Chen*1
1Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. 2Department of Emergency, Yuyao People’s Hospital, Yuyao 315400, China
Email: [email protected]

  •  Accepted: 25 November 2011
  •  Published: 26 December 2011

Abstract

This study aimed to determine the effects of valsartan on the proliferation and migration of isolated rat vascular smooth muscle cells (VSMCs) and the expression of phospho-p42/44 mitogen-activated protein kinase (MAPK) promoted by angiotensin II (Ang II). VSMCs from the rat thoracic aorta were cultured by attachment-block culture. VSMCs’ proliferation and migration were measured by MTT assay and migration chamber system, respectively. Phospho-p42/44 MAPK expression was determined by western blot. Our results reveal that valsartan inhibits Ang II-induced VSMCs’ proliferation and migration via suppression of Ang II-induced phospho-P42/44 MAPK expression.

 

Key words: Vascular smooth muscle, valsartan, angiotensin II, mitogen-activated protein kinase.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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