African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12482

Review

Review of somatic cell nuclear transfer in pig

Suchitra Muenthaisong1,2, Andras Dinnyes1,2,3 and  Tshimangadzo Lucky Nedambale4,5,6*
1Molecular Animal Biotechnology Laboratory, Szent Istvan University, H-2100 Gödöllö, Hungary. 2 BioTalentum Ltd, H-2100 Gödöllö, Hungary. 3Dept. of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands 4Agricultural Research Council (ARC), Animal Production Institute, Germplasm Conservation and Reproductive Biotechnologies, Irene, 0062, South Africa. 5Tshwane University of Technology, Department of Animal Sciences, Private Bag X680, Pretoria 0001, South Africa. 6University of the Free State, Department of Animal, Wildlife and Grassland Sciences, P.O. Box 339, Bloemfontein, South Africa.
Email: [email protected]

  •  Accepted: 30 September 2011
  •  Published: 30 November 2011

Abstract

It is now more than 8 years, since the first cloned pig from nuclear transfer wasreported. Success of somatic cell nuclear transfer (SCNT) in pig is still low compared to that in bovine. Embryonic and neonatal abnormalities of cloned piglets are probably a result of incorrect or incomplete reprogramming of the transferred donor cell nuclei. Recently, technical refinements have resulted in a considerable increase of SCNT efficiency. The current level of efficiency is already sufficient for special purposes with high scientific and commercial impact including xenotransplantation, generation of human disease models and for biomedical studies. In this paper, we review current pig cloning methodologies for the technical and potential applications.

 

Key words: Pig, somatic cell, nuclear transfer, oocyte and embryo.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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