African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Short Communication

In vitro and in vivo anticancer activities of a novel antibiotic

Chen Xiaoxi
Basic Medicine College, Zhejiang Chinese Medicine University, Binjiang District, Hangzhou City, Zhejiang Province, Postcode: 310053, People’s Republic of China.
Email: [email protected]

  •  Accepted: 24 March 2011
  •  Published: 03 August 2011

Abstract

IC50 for nine cancer cell lines was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays. In KM mice bearing sarcoma S180 that was treated with subcutaneous (s.c.) injection of antibiotic BS, marked cures were obtained. In terms of tumor weight, the treated/control = 0.43. The conclusion is that BS merit further investigation as a potential anti-cancer candidate drug.

 

Key word: Antibiotic, Bacillus subtilis, in vivo, in vitro, antitumor.

Abbreviation

MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; s.c, subcutaneous.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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