African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Jabuticaba [Pliniajaboticaba (Vell.) Berg] skins decrease lipid peroxidation: Hepatoprotective and antihyperlipidemic effects

LAGE Fabíola Fonseca
  • LAGE Fabíola Fonseca
  • Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras - UFLA, PO Box 3037, Zip Code 37200.000, Lavras, MG, Brazil.
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SIMÃO, Anderson Assaid
  • SIMÃO, Anderson Assaid
  • Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras - UFLA, PO Box 3037, Zip Code 37200.000, Lavras, MG, Brazil.
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GUEDES Mayara Neves Santos
  • GUEDES Mayara Neves Santos
  • Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras - UFLA, PO Box 3037, Zip Code 37200.000, Lavras, MG, Brazil.
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RAMOS Vinicius de Oliveira
  • RAMOS Vinicius de Oliveira
  • Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras - UFLA, PO Box 3037, Zip Code 37200.000, Lavras, MG, Brazil.
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SOUSA Raimundo Vicente de
  • SOUSA Raimundo Vicente de
  • Veterinary Medicine Laboratory, Universidade Federal de Lavras - UFLA, Zip Code 37200.000, Lavras, MG, Brazil.
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CORRÊA Angelita Duarte
  • CORRÊA Angelita Duarte
  • Chemistry Department, Biochemistry Laboratory, Universidade Federal de Lavras - UFLA, PO Box 3037, Zip Code 37200.000, Lavras, MG, Brazil.
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  •  Received: 20 December 2013
  •  Accepted: 25 February 2014
  •  Published: 12 March 2014

Abstract

The effect of Jabuticaba [Plinia jaboticaba (Vell.) Berg] Skin Flour (JSF) was studied on peroxidation, plasma and hepatic lipid profiles of female rats, as well as quantification and characterization of phenolic compounds. The animals were divided into four groups of eight rats. The groups received 0 (control); 0.5; 1.5 and 3.0 g JSF per 100 g diet. The diet with 3.0% JSF increased the HDL level by 20.23% compared to the control. The groups that received JSF had lower AST and ALT activities, when compared to the control group. There was a decrease of macro vesicular steatosis in the liver of animals fed the diet supplemented with 3.0% JSF. The diets containing 1.5% and 3.0% JSF reduced lipid peroxidation in the liver by about 50%. JSF was effective in protecting against dyslipidemia, because it increased the serum level of HDL cholesterol, showed a good antioxidant activity and demonstrated hepatoprotective effect.
 
Key words: Plinia jaboticaba, phenolic compounds, HDL cholesterol, antioxidant action, HPLC.
 

Abbreviation

Abbreviations: ABTS, 2,2′-Azinobis-(3-etilbenzotiazolin-6-sulphonic) acid; ADC, average daily consumption; ADG, average daily weight gain; ALT, alanine aminotransferase; AOAC, association of official analytical chemists; AST, aspartate aminotransferase; DM, dry matter; FER, feed efficiency ratio; GGT, gamma glutamyl transferase; HDLc, high-density lipoprotein cholesterol; HPLC, high-performance liquid chromatography; JSF, jabuticaba skin flour; LDLc, low-density lipoprotein cholesterol; MDA, malondialdehyde acid; NFE, nitrogen-free extract; TBARS, thiobarbituric acid reactive substances.