African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12486

Full Length Research Paper

Ethanol extract of Hedyotis diffusa willd. induction of apoptosis via PI3K/Akt and XIAP pathways in human leukemic THP-1 cells

Jia-He Wang1*, Yi-Jun Zhou2, Dong-Mei Yue3, Xue Bai1 and Ping He1
1Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. 2Department of endocrinology and metabolism, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China. 3Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Email: [email protected]

  •  Accepted: 13 June 2011
  •  Published: 22 August 2011

Abstract

Hedyotis diffusa (H. diffusa) Willd. is known to induce apoptosis in cancer cells. However, the molecular mechanism of its anti-cancer activity has not been fully elucidated. In this study, we found that the ethanol extract of H. diffusa Willd. (EEHDW) reduced cell viability and induced apoptosis in a dose- and time-dependent manner in human leukemic THP-1 cells. The induction of apoptosis was also accompanied by the down regulation of PI3K/Akt and the inhibitor of apoptosis protein (IAP) family proteins. Moreover, we observed that EEHDW treatment resulted in activation of caspase-3, which may partly explain the anti-cancer activity of EEHDW.

 

Key words: Hedyotis diffusa Willd., THP-1, apoptosis, caspase.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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