African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Effects of recombinant human nerve growth factor on cervical cancer

Huaiping Shi1#, Wenye Li1#, Guoxia Geng2, Qingwang Li1, 3* and Junjie Gao1
1College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China. 2College of veterinary medicine, Northwest A&F University, Yangling, Shaanxi 712100, China. 3College of Environment and Chemistry Engineering, Yanshan University, Qinhuangdao, HeBei 066004, China.
Email: [email protected]

  •  Accepted: 28 January 2011
  •  Published: 25 July 2011

Abstract

Nerve growth factor (NGF) plays a crucial role in the life of the sympathetic and sensory nervous systems. However, the roles of NGF to cervical cancer remain deeply unknown. This study investigated the effect of recombinant human nerve growth factor (rhNGF) on cervical cancer. It was found that the proliferation of helacells was inhibited by rhNGF and there were some apoptotic-like cell deaths. After tumor modeling of mice implanted U14 cells, it was shown that the growth of tumor tissues was inhibited in response to rhNGF and the concentration of virus been rhNGF was not more than 1.0×107 pfu/ml. In addition, the immune abilities of thymus and spleen were improved by rhNGF. Finally, it was shown that SOD level of tumor tissues was improved under the right concentration of rhNGF. Therefore, the mentioned result showed that cervical cancer is probably treated by rhNGF, which is depended on the concentration of rhNGF.

 

Key words: rhNGF, cervical cancer, tumor inhibition.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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