African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Polymorphisms in IL-10 (-1082) and IFN-𝛾, (+874) cytokine genes associated with resistance or susceptibility to Schistosoma haematobium infection in primary school children of Mount Darwin, Zimbabwe

Tendai Makwikwi
  • Tendai Makwikwi
  • Biochemistry Department, Faculty of Science, University of Zimbabwe, Harare, Zimbabwe.
  • Google Scholar
Takafira Mduluza
  • Takafira Mduluza
  • Biochemistry Department, Faculty of Science, University of Zimbabwe, Harare, Zimbabwe.
  • Google Scholar


  •  Received: 22 January 2019
  •  Accepted: 21 February 2019
  •  Published: 13 March 2019

References

Aragon AD, Imani RA, Blackburn VR, Cupit PM, Melman SD, Goronga T, Webb T, Loker ES, Cunningham C (2009). Towards an understanding of the mechanism of action of praziquantel. Molecular and Biochemical Parasitology 164(1): 57-65.
Crossref

 

Chevillard C, Moukoko C, Elwali N, Bream J, Kouriba B, Argiro, L, Rahoud S, Mergani A, Henri S, Gaudart J, Mohamed-Ali Q, Young H, Dessein A (2003). IFN- Polymorphisms (IFN- +2109 and IFN- +3810) Are Associated with Severe Hepatic Fibrosis in Human Hepatic Schistosomiasis (Schistosoma mansoni). The Journal of Immunology 171(10):5596-5601.
Crossref

 

Chitsulo L, Engels D, Montresor A, Savioli L (2000). The global status of schistosomiasis and its control. Acta tropica 77(1):41-51.
Crossref

 

Coutinho HM, Leenstra T, Acosta L, Lisu M, Jarilla B, Jiz M, A, Langdon GC, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF (2006). Pro-inflammatory cytokines and C-Reactive Protein are associated with undernutrition in the context of Schistosoma japonicum infection. American Journal of Tropical Medicine and Hygiene 75(4):720-726.
Crossref

 

Gasim GI, Bella A, Adam I (2015). Schistosomiasis, hepatitis B and hepatitis C co-infection. Virology Journal 12:19 
Crossref

 

Kwiatkowski D (2000). Genetic dissection of the molecular pathogenesis of severe infection. Intensive Care Medicine 26(1):89-97.
Crossref

 

Leenstra T, Acosta LP, Langdon GC, Manalo DL, Su L, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF (2006). Schistosoma japonica, anaemia, and iron status in children, adolescents and young adults in Leyte, Philippines. American Journal of Clinical Nutrition 83(2):371-379.
Crossref

 

Mduluza T, Gori E, Chitongo, P, Midzi N, Ruwona T, Soko W, Mlambo G, Mutambu SL, Kumar N (2013). Analysis of TNF-α and IL-10 gene polymorphisms in Zimbabwean children exposed to malaria. African Journal of Biotechnology 12(10):1034-1039.

 

Ministry of Health and Child Welfare (2010). National schistosomiasis and soil transmitted helminth report, Ministry of Health and Child Welfare report services, Zimbabwe, 16.

 

Ndhlovu P (1994). Zimbabwe National Schistosomiasis Survey. Ministry of Health Report, Zimbabwe, 14.

 

Perrey C, Turner SJ, Pravica V, Howell WM, Hutchinson I (1999). ARMS-PCR methodologies to determine IL-10, TNF-α, TNF-β and TGF-β 1 gene polymorphisms. Transplant Immunology 7(2):127–128.
Crossref

 

Person B, Ali SM, A'Kadir FM, Ali JN, Mohammed UA, Mohammed KA, Rollinson D, Knopp S (2016). Community knowledge , perceptions, and practices associated with urogenital schistosomiasis among school-aged children in Zanzibar,United Republic of Tanzania. PLOS Neglected Tropical Diseases 10(7):e0004814. 
Crossref

 

Rees LE, Wood NA, Gillespie KM, Lai KN, Gaston K, Mathieson PW (2002). The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance. Cellular and Molecular Life Sciences 59(3):560-569.
Crossref

 

Rowel C, Fred B, Betson M, Sousa-Figueiredo JC, Kabatereine P, Stothard JR (2015). Environmental epidemiology of intestinal schistosomiasis in Uganda: Population dynamics of Biomphalaria (Gastropoda: Planorbidae) in Lake Albert and Lake Victoria with observations on natural infections with digenetic trematodes. Biomedical Research International, 
Crossref

 

Upperman JS, Pillage G, Siddiqi MQ, Zeevi A, Kelly N, Ford HR, Kammerer C, Spolarics Z (2005). Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients. Shock 23(3):197-201.

 

Wami WM (2015). Paediatric schistosomiasis: Diagnosis, morbidity and treatment, D.Phil Thesis, University of Edinburgh.

 

Wami WM, Nausch N, Midzi N, Gwisai R, Mduluza T, Woolhouse M, Mutapi F (2015). Identifying and evaluating field indicators of urogenital schistosomiasis-related morbidity in preschool-aged children. PLOS Neglected Tropical Diseases 9(3):e0003649. 
Crossref

 

Wilson RA (1998). Interferon gamma is a key cytokine in lung phase immunity to schistosomes but what is its precise role? Brazilian Journal of Medical and Biological Research 31(1):157-161
Crossref