African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Study of interaction between lysozyme-aminoglycosides and penicillin

Anand Krishnamurthy1*, Sudarsanam D1, Anantharamanan R.3 and Najmeh Alirezaie2
  1Department of Advance Zoology and Biotechnology, Loyola College, Chennai, India. 2Research Center of Otolaryngology, Head and Neck Surgery, Hazrat Rasoul Akram Hospital Complex, Iran University of Medical Sciences, Tehran, Iran. 3Institute of Computational Biology, India.
Email: [email protected]

  •  Accepted: 15 November 2010
  •  Published: 30 June 2013



The interaction between aminoglycosides-lysozyme and penicillin-lysozyme was studied by using UV and IR spectroscopy. The study was started with the purification of lysozyme from hen, quail, duck and pigeon and designated as HEWL, QEWL, DEWL and PEWL, respectively. Aminoglycosides (kanamycin and streptomycin) and penicillin (ampicillin) interactions with lysozyme were explored in this investigation. The study provides useful clinical information for the compatibility and use of drugs via the reaction mechanism at the molecule level.


Key words: UV and IR spectroscopy, lysozyme, aminoglycosides, penicillin.