African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Efficacy of Dissotis rotundifolia on Trypanosoma brucei brucei infection in rats

Abdullahi Mann1*, Evans C. Egwim2, Barnabas Banji1, Nda-Umar Abdukadir1, Mohammed Gbate1 and J. T. Ekanem3
  1Department of Science Laboratory Technology, Federal Polytechnic Bida, P. M. B. 55, Bida, Niger State, Nigeria. 2Department of Biochemistry, Federal University of Technology Minna, P. M. B. 65, Minna, Niger State, Nigeria. 3Department of Biochemistry, University of Ilorin, P. M. B. 1515, Ilorin, Kwara State, Nigeria.
Email: [email protected]

  •  Accepted: 19 December 2008
  •  Published: 31 January 2009



The therapeutic potential of the crude extract of Dissotis rotundifolia was   investigated in rats infected with Trypanosoma b. brucei. Animals were treated orally or intraperitoneally at 200, 600 and 800 mg/kg body weight. At 800 mg/kg, parasitemia was reduced by 66.7 and 78.4% after oral and intraperitoneal administration respectively. In vitro exposure of blood forms to high concentration (800 mg/kg) crude extract test resulted in complete paralysis or killing within 45 s of exposure. It is concluded that D. rotundifolia may contain antitrypanosomal constituents.


Key words: Efficacy, trypanosoma, parasitemia, Dissotis rotundifolia, antitrypanosomal activity.