African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Antimalarial pyronaridine resistance may be associated with elevated MDR-1 gene expression profiles but not point mutation in Plasmodium berghei ANKA isolates

Shadrack Kanyonji Kimani
  • Shadrack Kanyonji Kimani
  • School of Life Sciences, Northeast Normal University, Changchun, China.
  • Google Scholar
Jacob Manyiwa Shume
  • Jacob Manyiwa Shume
  • School of Pure and Applied Sciences, Karatina University, Karatina, Kenya.
  • Google Scholar


  •  Received: 27 June 2020
  •  Accepted: 13 August 2020
  •  Published: 31 October 2020

References

Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990). Basic Local Alignment Search Tool. Journal of Molecular Biology 215:403-10.
Crossref

 

Ashley Elizabeth A, Phyo PA (2018). Drugs in Development for Malaria. Drugs 78(9):861-879. 
Crossref

 
 

Auparakkitanon S, Chapoomram S, Kuaha K, Chirachariyavej T, Wilairat P(2006). Targeting of Hematin by the Antimalarial Pyronaridine.Antimicrobial Agents and Chemotherapy 50(6):2197-2200.
Crossref

 
 

Chang C, Lin-Hua T, Jantanavivat C (1992). Studies on a New Antimalarial Compound: Pyronaridine. Transactions of the Royal Society of Tropical Medicine and Hygiene 86(1):7-10.
Crossref

 
 

Croft SL, Duparc S, Arbe-barnes SJ, Carl Craft J, Shin C, Fleckenstein L, Borghini-fuhrer I, Rim H (2012). Review of Pyronaridine Anti-Malarial Properties and Product Characteristics. Malaria Journal 11(4):270.
Crossref

 
 

Dipanjan B, Shivaprakash G, Balaji O (2017). Triple Combination Therapy and Drug Cycling-Tangential Strategies for Countering Artemisinin Resistance. Current Infectious Disease Reports 19(7):1-7.
Crossref

 
 

Dorn A, Rani SV, Matile H, Jaquet C, Vennerstrom JL, Ridley RG (1998). An Assessment of Drug-Haematin Binding as a Mechanism for Inhibition of Haematin Polymerisation by Quinoline Antimalarials. Biochemical Pharmacology 55(97):727-736.
Crossref

 
 

Duraisingh MT, Cowman AF (2005). Contribution of the Pfmdr1 Gene to Antimalarial Drug-Resistance. Acta Tropica 94:181-190.
Crossref

 
 

Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S (2004). Antimalarial Drug Discovery: Efficacy Models for Compound Screening. Nature Reviews Drug Discovery 3(6):509-520.
Crossref

 
 

Gupta S, Thapar MM, Mariga ST, Wernsdorfer WH,Björkman A (2002). Plasmodium falciparum: In Vitro Interactions of Artemisinin with Amodiaquine, Pyronaridine, and Chloroquine. Experimental Parasitology 100(1):28-35.
Crossref

 
 

Hanboonkunupakarn B, White NJ (2015). The Threat of Antimalarial Drug Resistance. Tropical Diseases, Travel Medicine and Vaccines 2(1):1-5.
Crossref

 
 

Hastings IM, Hodel EM (2014). Pharmacological Considerations in the Design of Anti-Malarial Drug Combination Therapies - Is Matching Half-Lives Enough? Malaria Journal 13 (1):1-15.
Crossref

 
 

Henrich PP, Brien CO, Sáenz FE, Cremers S, Kyle DE, Fidock DA (2014). Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model. Antimicrobial Agents and Chemotherapy 58(1):183-95.
Crossref

 
 

Hien TT, Thuy-Nhien NT, Phu HN, Boni MF, Thanh NV, Nha-Ca NT, Thai L (2012). In Vivo Susceptibility of Plasmodium falciparum to Artesunate in Binh Phuoc Province, Vietnam. Malaria Journal 11:1-11.
Crossref

 
 

Janse C, Ramesar J, Waters A (2004). Plasmodium Berghei: General Parasitological Methods.Leiden University Medical Center, The Netherlands pp. 26-27.

 
 

Kiboi, DM, Irungu B, Orwa J, Kamau L, Ochola-oyier LI, Ngángá J, Nzila A (2014). Experimental Parasitology Piperaquine and Lumefantrine Resistance in Plasmodium berghei ANKA Associated with Increased Expression of Ca 2 + / H + Antiporter and Glutathione Associated Enzymes. Experimental Parasitology 147:23-32.
Crossref

 
 

Kimani SK, Ng JK, Kariuki DW, Kinyua J, Kimani FT, Kiboi DM (2014). Plasmodium berghei ANKA : Selection of Pyronaridine Resistance in Mouse Model. African Journal of Biochemistry Research 8(6):111-17.
Crossref

 
 

Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018). MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Molecular Biology and Evolution 35(6):1547-1549.
Crossref

 
 

Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Aye M, Lindegardh N (2013). Reduced Susceptibility of Plasmodium falciparum to Artesunate in Southern Myanmar. PLoS ONE 8(3).
Crossref

 
 

Li GD, Liu SQ, Ye XY, Qu FY (1995). Detection of 54-KDa Protein Overexpressed by Chloroquine-Resistant Plasmodium berghei ANKA Strain in Pyronaridine-Resistant P. berghei ANKA Strain] (in Chinese). Pharmacologica Sinica 16(1):17-20.

 
 

Li Q, Hickman M (2015). The Impact of Pharmacokinetic Mismatched Antimalarial Drug Combinations on the Emergence and Spread of Drug Resistant Parasites. Basic Pharmacokinetic Concepts and Some Clinical Applications 1:1-32.
Crossref

 
 

Livak KJ, Schmittgen TD(2001). Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-ΔΔCT Method. Methods 25(4):402-408.
Crossref

 
 

Menard D, Dondorp A (2017). Antimalarial Drug Resistance: A Threat to Malaria Elimination. Cold Spring Harb Perspect Medicine. 
Crossref

 
 

Merkli B, Richle RW (1980). Studies on the Resistance to Single and Combined Antimalarials in the Plasmodium berghei Mouse Model. Acta Tropica 37:228-231.

 
 

Mishra M, Mishra VK, Kashaw V, Iyer AK, Kashaw SK (2017). Comprehensive Review on Various Strategies for Antimalarial Drug Discovery. European Journal of Medicinal Chemistry 125:1300-1320.
Crossref

 
 

Ouji M, Augereau JM, Paloque L, Benoit-Vical F (2018). Plasmodium falciparum Resistance to Artemisinin-Based Combination Therapies: A Sword of Damocles in the Path toward Malaria Elimination. Parasite 25:24-30.
Crossref

 
 

Park SH, Pradeep K (2010). Absorption, Distribution, Excretion, and Pharmacokinetics of C 14 -Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats. Journal of Biomedicine and Biotechnology 59:1-9.
Crossref

 
 

Peters W, Robinson BL (1992). The Chemotherapy of Rodent Malaria. XLVII. Studies on Pyronaridine and Other Mannich Base Antimalarials. Annals of Tropical Medicine and Parasitology 86(5):455-465.
Crossref

 
 

Pradines B, Briolant S, Henry M, Oeuvray C, Baret E, Amalvict R, Didillon E, Rogier C (2010). Absence of Association between Pyronaridine in Vitro Responses and Polymorphisms in Genes Involved in Quinoline Resistance in Plasmodium falciparum. Malaria Journal 9:339.
Crossref

 
 

Qi J, Yang CZ, Wang CY, Wang SB, Yang M, Wang JH (2002). Function and Mechanism of Pyronaridine: A New Inhibitor of P-Glycoprotein-Mediated Multidrug Resistance. Acta Pharmaceutica Sinica 23:544-550.

 
 

Qi J, Wang S, Liu G, Peng H, Wang J, Zhu Z, Yang C (2004). Pyronaridine, a Novel Modulator of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells in Vitro and in Vivo. Biochemical and Biophysical Research Communications 319(4):1124-1131.
Crossref

 
 

Ramharter M, Kurth F, Schreier AC, Nemeth J, Von Glasenapp I, Schlie M, Kammer J (2008). Fixed-Dose Pyronaridine-Artesunate Combination for Treatment of Uncomplicated Falciparum Malaria in Pediatric Patients in Gabon. Journal of Infectious Diseases 198:911-19.
Crossref

 
 

Rathod P, Mcerlean T, Lee P (1997). Variations in Frequencies of Drug Resistance in Plasmodium falciparum. Proceedings of the National Academy of Sciences 94:9389-9393.
Crossref

 
 

Rogers WO, Sem R, Tero T, Chim P, Lim P, Muth S, Socheat D, Ariey F, Wongsrichanalai C(2009). Failure of Artesunate-Mefloquine Combination Therapy for Uncomplicated Plasmodium falciparum Malaria in Southern. Malaria Journal 9:1-9.
Crossref

 
 

Tang Y, Ye Q, Huang H, Zheng W (2020). An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance Current Molecular Medicine 20(8):583-592.
Crossref

 
 

Tse EG, Korsik M, Todd MH (2019). The Past, Present and Future of Anti-Malarial Medicines. Malaria Journal 18(1):1-21.
Crossref

 
 

Vivas L, Rattray L, Stewart L, Bongard E, Robinson BL, Peters W, Croft SL (2008). Anti-Malarial Efficacy of Pyronaridine and Artesunate in Combination in Vitro and in Vivo. Acta Tropica 105(3):222-228.
Crossref

 
 

World Health Organization (WHO) (2017). World malaria report 2017. 
Crossref

 
 

World Health Organization (WHO) (2020). The use artesunate-pyronaridine for the treatmnt of uncomplicated malaria. 

View

 
 

Woodrow CJ, Krishna S (2006). Antimalarial Drugs : Recent Advances in Molecular Determinants of Resistance and Their Clinical Significance. Cell Molecular Life Science 63:1586-1596.
Crossref

 
 

Wu LJ, Rabbege JR, Nagasawa H, Jacobs G, Aikawa M (1988). Morphological Effects of Pyronaridine on Malarial Parasites. American Journal of Tropical Medicine and Hygiene 9:87-89.