African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

In vitro effect of tigecycline against Mycobacterium tuberculosis and a review of the available drugs for tuberculosis

Ahmet Yilmaz Coban1*, Aydin Deveci2, Yeliz Tanriverdi Cayci1, Meltem Uzun3, Alper Akgunes4 and Belma Durupinar1
  1Department of Medical Microbiology, Ondokuz Mayis University, Medical School, Samsun, Turkey. 2Ondokuz Mayis University, Medical School, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey. 3Department of Medical Microbiology, Istanbul University, Istanbul Medical School, Istanbul, Turkey. 4Samsun Chest Diseases Hospital, Clinical Microbiology Laboratory, Samsun, Turkey.
Email: [email protected]

  •  Accepted: 17 January 2011
  •  Published: 04 February 2011



The study aimed to investigate the effectiveness of a novel antibiotic drug tigecycline on clinical isolates of Mycobacterium tuberculosis and, reviewing defined anti-tuberculosis effects of available agents. Minimal inhibitory concentration (MIC) of tigecycline for 50 M. tuberculosisincluding multidrug-resistant (MDR) clinical isolates (20 MDR isolates) was determined by broth microdilution method in the study. Tigecycline MIC values were ranging between 8 and 64 µg/ml. However, there is not any defined break point for M. tuberculosis resistance. In conclusion, it seems that the in vitro effectiveness of tigecycline to M. tuberculosis is not good but further in vivo studies are needed.


Key words: Mycobacterium tuberculosis, tigecycline.