African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5210

Full Length Research Paper

Expanding drug resistance through integron acquisition in Salmonella spp. isolates obtained in Iran

Bahareh Rajaei1, Seyed Davar Siadat1,2*, Mohamad Reza Razavi3, Mohammad Reza Aghasadeghi2, Nahid Sepehri Rad1, Farzad Badmasti4, Somieh Khanjani Jafroodi3, Taraneh Rajaei5, Arfa Moshiri6, Saifuddin Javadian7
1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. 2Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran. 3Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran. 4Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran. 5Department of Immunology and Allergy, Mashhad University of Medical Sciences, Mashhad, Iran. 6Department of Biotechnology, Faculty of Allied Sciences, Tehran University of Medical Sciences, Tehran, Iran. 7Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Email: [email protected]

  •  Accepted: 15 July 2011
  •  Published: 18 August 2011

Abstract

A total eighty four epidemiologically unrelated clinical isolates of Salmonella entericaserovars were subjected to antimicrobial susceptibility testing and molecular detection of class 1 and 2 integrons. Eleven isolates (13.1%) which were resistant to at least 4 groups of antimicrobial agents considered as MDR (multidrug resistant) Salmonella serovars. PCR assays detected intI1 and intI2 genes in 50 (59.5%) and 14 (16.7%) of Salmonellaclinical isolates respectively. Emergence of MDR Salmonella serovars demonstrates that antimicrobial selection pressure is widespread and increased distribution of integron carrying gene cassettes which confer resistance to different antibiotics confirms that integron-mediated antibiotic resistance is considerable in our clinical settings.

 

Key words: Salmonella spp., integron, multidrug resistance (MDR).