Helicobacter pylori is associated with the development of a variety of gastroduodenal diseases. In this study, we evaluated the prevalence of H. pylori cagA and vacAgenotypes from a Northeastern Mexico population. DNA was extracted from 135 gastric biopsies from patients with gastric disease: 110 with chronic gastritis (CG) and 25 with intestinal metaplasia (IM). Polymerase Chain Reaction (PCR) was used to detect cagAand vacA (s1, s2, m1, m2) genes of H. pylori. The study showed that the dominant genotypes were cagA vacA s1/m1 43 (31.8%), followed by cagA vacA s2/m2 18 (13.3%) and cagA vacA s1/m2 3 (2.2%). This study did not find any presence of the genotypevacA s2/m1. For the genotype cagA vacA s1/m1, a significant association was found between its presence in patients with IM compared with patient with CG (P Ë‚ 0.05). In conclusion, the results show that the predominant genotype in the Northeastern Mexico population was cagA vacA s1/m1, which was found to be significantly associated with patients with IM.
Key words: Gastric biopsies; Helicobacter pylori; cagA; vacA; Chronic Gastritis; Intestinal Metaplasia
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