African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5211

Full Length Research Paper

Isolation and characterization of Streptomyces alboflavus SC11 producing desertomycin A

Li-Xia Fan1,3,4, Zheng-yan Guo2,4* and Wen-Jun Wu1,3,4*
1State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China. 2State Key Laboratory of Microbial  Resources, The Institue of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. 3Shaanxi Province Key Laboratory Research & Development on Botanical Pesticide, Northwest A&F University, Shaanxi 712100, P.R. China. 4Key Laboratory of Plant Protection Resources and Pest Integrated Management, Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China.
Email: [email protected]

  •  Accepted: 12 November 2012
  •  Published: 02 April 2013


An actinomycete, isolated from soil samples of western Sichuan Plateau of China, was identified as Streptomyces alboflavus SC11 by 16S rDNA analysis, and also cultural, morphological and physiological characteristics of the strain were recorded. From the fermentation broth of the strain, an antimicrobial ingredient was isolated and elucidated as desertomycin A, mainly by analysis of electrospray ionization tandem mass spectrometry (ESI-MS/MS), 1H nuclear magnetic resonance (NMR) and 13C NMR spectra data. Desertomycin A exhibited good antimicrobial potential against the pathogenic bacteria and fungi. Minimum inhibition concentration (MIC) values of desertomycin A were 3.9, 7.8 and 7.8 μg/ml against Bacillus cereusBacillus subtilis and Staphyloccocus aureus,respectively.


Key words: Streptomyces alboflavus SC11,Desertomycin A, 16S rDNA, Antimicrobial activities.